› 7aa7

X-ray diffraction
1.45Å resolution

Structure of SCOC pS12/pS18 LIR motif bound to GABARAPL1

Released:
DOI: 10.2210/pdb7aa7/pdb
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PDB entry 7aa7 coloured by chain, front view.
PDB entry 7aa7 coloured by chain, side view.
PDB entry 7aa7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Phosphorylation of the LIR Domain of SCOC Modulates ATG8 Binding Affinity and Specificity.
Wirth M, Mouilleron S, Zhang W, Sjøttem E, Princely Abudu Y, Jain A, Lauritz Olsvik H, Bruun JA, Razi M, Jefferies HBJ, Lee R, Joshi D, O'Reilly N, Johansen T, Tooze SA
OpenAccess logo J Mol Biol 433 166987 (2021)
PMID: 33845085

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190492 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Gamma-aminobutyric acid receptor-associated protein-like 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 123 amino acids
Theoretical weight: 14.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H0R8 (Residues: 1-117; Coverage: 100%)
Gene names: GABARAPL1, GEC1
Sequence domains: Autophagy protein Atg8 ubiquitin like
Short coiled-coil protein Chains: P, Q
Molecule details ›
Chains: P, Q
Length: 11 amino acids
Theoretical weight: 1.42 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q9UIL1 (Residues: 95-102; Coverage: 5%)
  • Best match: Q9UIL1-2 (Residues: 9-19)
Gene names: HRIHFB2072, SCOC, SCOCO

Ligands and Environments

1 bound ligand:
Ligand SAT 2 x SAT
1 modified residue:
Ligand SEP 4 x SEP

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P1
Unit cell:
a: 28.364Å b: 37.169Å c: 62.482Å
α: 81.751° β: 89.602° γ: 67.818°
R-values:
R R work R free
0.153 0.151 0.189
Expression systems:
  • Escherichia coli
  • Not provided

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Citations

1 review citation

Orchestrating serine/threonine phosphorylation and elucidating downstream effects by short linear motifs.
Kliche et al. (2022)
7 other articles

3 mentions without citation

Phosphorylation by casein kinase 2 enhances the interaction between ER-phagy receptor TEX264 and ATG8 proteins.
Chino et al. (2022)
2 more

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