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Human pre-Bact-2 spliceosome core structure

Source organism: Homo sapiens
Biochemical function: protein binding
Biological process: mRNA splicing, via spliceosome
Cellular component: nucleoplasm

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GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00400
Domain description: WD domain, G-beta repeat
Occurring in:
  1. Pre-mRNA-processing factor 17
  2. Pleiotropic regulator 1
The deposited structure of PDB entry 7aav contains 5 copies of Pfam domain PF00400 (WD domain, G-beta repeat) in Pleiotropic regulator 1. Showing 5 copies in chain F [auth G].
The deposited structure of PDB entry 7aav contains 5 copies of Pfam domain PF00400 (WD domain, G-beta repeat) in Pre-mRNA-processing factor 17. Showing 5 copies in chain H [auth 8] (this domain is out of the observed residue ranges!).

PF13921
Domain description: Myb-like DNA-binding domain
Occurring in:
  1. Cell division cycle 5-like protein
The deposited structure of PDB entry 7aav contains 2 copies of Pfam domain PF13921 (Myb-like DNA-binding domain) in Cell division cycle 5-like protein. Showing 2 copies in chain C [auth L].

PF02731
Domain description: SKIP/SNW domain
Occurring in:
  1. SNW domain-containing protein 1
The deposited structure of PDB entry 7aav contains 1 copy of Pfam domain PF02731 (SKIP/SNW domain) in SNW domain-containing protein 1. Showing 1 copy in chain L [auth v].

PF00679
Domain description: Elongation factor G C-terminus
Occurring in:
  1. 116 kDa U5 small nuclear ribonucleoprotein component
The deposited structure of PDB entry 7aav contains 1 copy of Pfam domain PF00679 (Elongation factor G C-terminus) in 116 kDa U5 small nuclear ribonucleoprotein component. Showing 1 copy in chain A [auth r].

PF03764
Domain description: Elongation factor G, domain IV
Occurring in:
  1. 116 kDa U5 small nuclear ribonucleoprotein component
The deposited structure of PDB entry 7aav contains 1 copy of Pfam domain PF03764 (Elongation factor G, domain IV) in 116 kDa U5 small nuclear ribonucleoprotein component. Showing 1 copy in chain A [auth r].

PF14492
Domain description: Elongation Factor G, domain III
Occurring in:
  1. 116 kDa U5 small nuclear ribonucleoprotein component
The deposited structure of PDB entry 7aav contains 1 copy of Pfam domain PF14492 (Elongation Factor G, domain III) in 116 kDa U5 small nuclear ribonucleoprotein component. Showing 1 copy in chain A [auth r].

PF03144
Domain description: Elongation factor Tu domain 2
Occurring in:
  1. 116 kDa U5 small nuclear ribonucleoprotein component
The deposited structure of PDB entry 7aav contains 1 copy of Pfam domain PF03144 (Elongation factor Tu domain 2) in 116 kDa U5 small nuclear ribonucleoprotein component. Showing 1 copy in chain A [auth r].

PF00009
Domain description: Elongation factor Tu GTP binding domain
Occurring in:
  1. 116 kDa U5 small nuclear ribonucleoprotein component
The deposited structure of PDB entry 7aav contains 1 copy of Pfam domain PF00009 (Elongation factor Tu GTP binding domain) in 116 kDa U5 small nuclear ribonucleoprotein component. Showing 1 copy in chain A [auth r].

PF16004
Domain description: 116 kDa U5 small nuclear ribonucleoprotein component N-terminus
Occurring in:
  1. 116 kDa U5 small nuclear ribonucleoprotein component
The deposited structure of PDB entry 7aav contains 1 copy of Pfam domain PF16004 (116 kDa U5 small nuclear ribonucleoprotein component N-terminus) in 116 kDa U5 small nuclear ribonucleoprotein component. Showing 1 copy in chain A [auth r].

PF00240
Domain description: Ubiquitin family
Occurring in:
  1. Ubiquitin-like protein 5
The deposited structure of PDB entry 7aav contains 1 copy of Pfam domain PF00240 (Ubiquitin family) in Ubiquitin-like protein 5. Showing 1 copy in chain Q [auth q].

PF04889
Domain description: Cwf15/Cwc15 cell cycle control protein
Occurring in:
  1. Spliceosome-associated protein CWC15 homolog
The deposited structure of PDB entry 7aav contains 1 copy of Pfam domain PF04889 (Cwf15/Cwc15 cell cycle control protein) in Spliceosome-associated protein CWC15 homolog. Showing 1 copy in chain D [auth R].

PF01125
Domain description: Pre-mRNA-splicing factor BUD31
Occurring in:
  1. Protein BUD31 homolog
The deposited structure of PDB entry 7aav contains 1 copy of Pfam domain PF01125 (G10 protein) in Protein BUD31 homolog. Showing 1 copy in chain B [auth Q].

PF00076
Domain description: RNA recognition motif
Occurring in:
  1. Pre-mRNA-splicing factor RBM22
The deposited structure of PDB entry 7aav contains 1 copy of Pfam domain PF00076 (RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)) in Pre-mRNA-splicing factor RBM22. Showing 1 copy in chain K [auth P] (this domain is out of the observed residue ranges!).

PF21369
Domain description: STL11, N-terminal
Occurring in:
  1. Pre-mRNA-splicing factor RBM22

PF12171
Domain description: Zinc-finger double-stranded RNA-binding
Occurring in:
  1. Zinc finger matrin-type protein 2
The deposited structure of PDB entry 7aav contains 1 copy of Pfam domain PF12171 (Zinc-finger double-stranded RNA-binding) in Zinc finger matrin-type protein 2. Showing 1 copy in chain M [auth N].

PF11831
Domain description: pre-mRNA splicing factor component
Occurring in:
  1. Cell division cycle 5-like protein
The deposited structure of PDB entry 7aav contains 1 copy of Pfam domain PF11831 (pre-mRNA splicing factor component) in Cell division cycle 5-like protein. Showing 1 copy in chain C [auth L] (this domain is out of the observed residue ranges!).

PF06991
Domain description: Microfibril-associated/Pre-mRNA processing
Occurring in:
  1. Microfibrillar-associated protein 1
The deposited structure of PDB entry 7aav contains 1 copy of Pfam domain PF06991 (Microfibril-associated/Pre-mRNA processing) in Microfibrillar-associated protein 1. Showing 1 copy in chain E [auth K].

PF12871
Domain description: Pre-mRNA-splicing factor 38-associated hydrophilic C-term
Occurring in:
  1. Pre-mRNA-splicing factor 38A
The deposited structure of PDB entry 7aav contains 1 copy of Pfam domain PF12871 (Pre-mRNA-splicing factor 38-associated hydrophilic C-term) in Pre-mRNA-splicing factor 38A. Showing 1 copy in chain I (this domain is out of the observed residue ranges!).

PF03371
Domain description: PRP38 family
Occurring in:
  1. Pre-mRNA-splicing factor 38A
The deposited structure of PDB entry 7aav contains 1 copy of Pfam domain PF03371 (PRP38 family) in Pre-mRNA-splicing factor 38A. Showing 1 copy in chain I.

PF08084
Domain description: PROCT (NUC072) domain
Occurring in:
  1. Pre-mRNA-processing-splicing factor 8
The deposited structure of PDB entry 7aav contains 1 copy of Pfam domain PF08084 (PROCT (NUC072) domain) in Pre-mRNA-processing-splicing factor 8. Showing 1 copy in chain J [auth A] (this domain is out of the observed residue ranges!).

PF01398
Domain description: JAB1/Mov34/MPN/PAD-1 ubiquitin protease
Occurring in:
  1. Pre-mRNA-processing-splicing factor 8
The deposited structure of PDB entry 7aav contains 1 copy of Pfam domain PF01398 (JAB1/Mov34/MPN/PAD-1 ubiquitin protease) in Pre-mRNA-processing-splicing factor 8. Showing 1 copy in chain J [auth A] (this domain is out of the observed residue ranges!).

PF12134
Domain description: PRP8 domain IV core
Occurring in:
  1. Pre-mRNA-processing-splicing factor 8
The deposited structure of PDB entry 7aav contains 1 copy of Pfam domain PF12134 (PRP8 domain IV core) in Pre-mRNA-processing-splicing factor 8. Showing 1 copy in chain J [auth A] (this domain is out of the observed residue ranges!).

PF10596
Domain description: U6-snRNA interacting domain of PrP8
Occurring in:
  1. Pre-mRNA-processing-splicing factor 8
The deposited structure of PDB entry 7aav contains 1 copy of Pfam domain PF10596 (U6-snRNA interacting domain of PrP8) in Pre-mRNA-processing-splicing factor 8. Showing 1 copy in chain J [auth A].

PF10597
Domain description: U5-snRNA binding site 2 of PrP8
Occurring in:
  1. Pre-mRNA-processing-splicing factor 8
The deposited structure of PDB entry 7aav contains 1 copy of Pfam domain PF10597 (U5-snRNA binding site 2 of PrP8) in Pre-mRNA-processing-splicing factor 8. Showing 1 copy in chain J [auth A].

PF10598
Domain description: RNA recognition motif of the spliceosomal PrP8
Occurring in:
  1. Pre-mRNA-processing-splicing factor 8
The deposited structure of PDB entry 7aav contains 1 copy of Pfam domain PF10598 (RNA recognition motif of the spliceosomal PrP8) in Pre-mRNA-processing-splicing factor 8. Showing 1 copy in chain J [auth A].

PF08083
Domain description: PROCN (NUC071) domain
Occurring in:
  1. Pre-mRNA-processing-splicing factor 8
The deposited structure of PDB entry 7aav contains 1 copy of Pfam domain PF08083 (PROCN (NUC071) domain) in Pre-mRNA-processing-splicing factor 8. Showing 1 copy in chain J [auth A].

PF08082
Domain description: PRO8NT (NUC069), PrP8 N-terminal domain
Occurring in:
  1. Pre-mRNA-processing-splicing factor 8
The deposited structure of PDB entry 7aav contains 1 copy of Pfam domain PF08082 (PRO8NT (NUC069), PrP8 N-terminal domain) in Pre-mRNA-processing-splicing factor 8. Showing 1 copy in chain J [auth A].

Rfam RNA families (Rfam)
RF00004
Domain description: U2 spliceosomal RNA
Occurring in:
  1. U2 snRNA
The deposited structure of PDB entry 7aav contains 1 copy of Rfam domain RF00004 (U2 spliceosomal RNA) in U2 snRNA. Showing 1 copy in chain N [auth 2].

RF00020
Domain description: U5 spliceosomal RNA
Occurring in:
  1. U5 snRNA
The deposited structure of PDB entry 7aav contains 1 copy of Rfam domain RF00020 (U5 spliceosomal RNA) in U5 snRNA. Showing 1 copy in chain O [auth 5].

RF00026
Domain description: U6 spliceosomal RNA
Occurring in:
  1. U6 snRNA
The deposited structure of PDB entry 7aav contains 1 copy of Rfam domain RF00026 (U6 spliceosomal RNA) in U6 snRNA. Showing 1 copy in chain P [auth 6].

InterPro InterPro annotations
IPR001680
Domain description: WD40 repeat
Occurring in:
  1. Pre-mRNA-processing factor 17
  2. Pleiotropic regulator 1
IPR000795
Domain description: Translational (tr)-type GTP-binding domain
Occurring in:
  1. 116 kDa U5 small nuclear ribonucleoprotein component
IPR001748
Domain description: Pre-mRNA-splicing factor BUD31
Occurring in:
  1. Protein BUD31 homolog
IPR001005
Domain description: SANT/Myb domain
Occurring in:
  1. Cell division cycle 5-like protein
IPR000504
Domain description: RNA recognition motif domain
Occurring in:
  1. Pre-mRNA-splicing factor RBM22
IPR020472
Domain description: G-protein beta WD-40 repeat
Occurring in:
  1. Pleiotropic regulator 1
IPR019775
Domain description: WD40 repeat, conserved site
Occurring in:
  1. Pre-mRNA-processing factor 17
  2. Pleiotropic regulator 1
IPR000640
Domain description: Elongation factor EFG, domain V-like
Occurring in:
  1. 116 kDa U5 small nuclear ribonucleoprotein component
IPR005517
Domain description: Translation elongation factor EFG/EF2, domain IV
Occurring in:
  1. 116 kDa U5 small nuclear ribonucleoprotein component
IPR035647
Domain description: EF-G domain III/V-like
Occurring in:
  1. 116 kDa U5 small nuclear ribonucleoprotein component
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. 116 kDa U5 small nuclear ribonucleoprotein component
IPR018230
Domain description: BUD31/G10-related, conserved site
Occurring in:
  1. Protein BUD31 homolog
IPR000571
Domain description: Zinc finger, CCCH-type
Occurring in:
  1. Pre-mRNA-splicing factor RBM22
IPR017930
Domain description: Myb domain
Occurring in:
  1. Cell division cycle 5-like protein
IPR005037
Domain description: Pre-mRNA-splicing factor 38
Occurring in:
  1. Pre-mRNA-splicing factor 38A
IPR000555
Domain description: JAB1/MPN/MOV34 metalloenzyme domain
Occurring in:
  1. Pre-mRNA-processing-splicing factor 8
IPR021983
Domain description: PRP8 domain IV core
Occurring in:
  1. Pre-mRNA-processing-splicing factor 8
IPR012337
Domain description: Ribonuclease H-like superfamily
Occurring in:
  1. Pre-mRNA-processing-splicing factor 8
IPR036322
Domain description: WD40-repeat-containing domain superfamily
Occurring in:
  1. Pre-mRNA-processing factor 17
  2. Pleiotropic regulator 1
IPR015943
Domain description: WD40/YVTN repeat-like-containing domain superfamily
Occurring in:
  1. Pre-mRNA-processing factor 17
  2. Pleiotropic regulator 1
IPR004015
Domain description: SKI-interacting protein SKIP, SNW domain
Occurring in:
  1. SNW domain-containing protein 1
IPR017862
Domain description: SKI-interacting protein, SKIP
Occurring in:
  1. SNW domain-containing protein 1
IPR035655
Domain description: 116kDa U5 small nuclear ribonucleoprotein component, C-terminal
Occurring in:
  1. 116 kDa U5 small nuclear ribonucleoprotein component
IPR014721
Domain description: Small ribosomal subunit protein uS5 domain 2-type fold, subgroup
Occurring in:
  1. 116 kDa U5 small nuclear ribonucleoprotein component
IPR020568
Domain description: Ribosomal protein uS5 domain 2-type superfamily
Occurring in:
  1. 116 kDa U5 small nuclear ribonucleoprotein component
IPR041095
Domain description: Elongation Factor G, domain II
Occurring in:
  1. 116 kDa U5 small nuclear ribonucleoprotein component
IPR004161
Domain description: Translation elongation factor EFTu-like, domain 2
Occurring in:
  1. 116 kDa U5 small nuclear ribonucleoprotein component
IPR009000
Domain description: Translation protein, beta-barrel domain superfamily
Occurring in:
  1. 116 kDa U5 small nuclear ribonucleoprotein component
IPR044121
Domain description: Snu114, GTP-binding domain
Occurring in:
  1. 116 kDa U5 small nuclear ribonucleoprotein component
IPR005225
Domain description: Small GTP-binding domain
Occurring in:
  1. 116 kDa U5 small nuclear ribonucleoprotein component
IPR031950
Domain description: 116kDa U5 small nuclear ribonucleoprotein component, N-terminal
Occurring in:
  1. 116 kDa U5 small nuclear ribonucleoprotein component
IPR000626
Domain description: Ubiquitin-like domain
Occurring in:
  1. Ubiquitin-like protein 5
IPR039732
Domain description: Ubiquitin-like modifier Hub1/Ubl5
Occurring in:
  1. Ubiquitin-like protein 5
IPR029071
Domain description: Ubiquitin-like domain superfamily
Occurring in:
  1. Ubiquitin-like protein 5
IPR006973
Domain description: Pre-mRNA-splicing factor Cwf15/Cwc15
Occurring in:
  1. Spliceosome-associated protein CWC15 homolog
IPR012677
Domain description: Nucleotide-binding alpha-beta plait domain superfamily
Occurring in:
  1. Pre-mRNA-splicing factor RBM22
IPR035979
Domain description: RNA-binding domain superfamily
Occurring in:
  1. Pre-mRNA-splicing factor RBM22
IPR036855
Domain description: Zinc finger, CCCH-type superfamily
Occurring in:
  1. Pre-mRNA-splicing factor RBM22
IPR039171
Domain description: Pre-mRNA-splicing factor Cwc2/Slt11
Occurring in:
  1. Pre-mRNA-splicing factor RBM22
IPR022755
Domain description: Zinc finger, double-stranded RNA binding
Occurring in:
  1. Zinc finger matrin-type protein 2
IPR003604
Domain description: Matrin/U1-C-like, C2H2-type zinc finger
Occurring in:
  1. Zinc finger matrin-type protein 2
IPR036236
Domain description: Zinc finger C2H2 superfamily
Occurring in:
  1. Zinc finger matrin-type protein 2
IPR040107
Domain description: U4/U6.U5 small nuclear ribonucleoprotein component Snu23
Occurring in:
  1. Zinc finger matrin-type protein 2
IPR021786
Domain description: Pre-mRNA splicing factor component Cdc5p/Cef1, C-terminal
Occurring in:
  1. Cell division cycle 5-like protein
IPR047240
Domain description: Pre-mRNA splicing factor component CDC5L/Cef1, second SANT/myb-like domain
Occurring in:
  1. Cell division cycle 5-like protein
IPR009057
Domain description: Homedomain-like superfamily
Occurring in:
  1. Cell division cycle 5-like protein
IPR047242
Domain description: Pre-mRNA splicing factor component CDC5L/Cef1
Occurring in:
  1. Cell division cycle 5-like protein
IPR009730
Domain description: Micro-fibrillar-associated protein 1, C-terminal
Occurring in:
  1. Microfibrillar-associated protein 1
IPR033194
Domain description: Microfibrillar-associated protein 1
Occurring in:
  1. Microfibrillar-associated protein 1
IPR024767
Domain description: Pre-mRNA-splicing factor 38, C-terminal
Occurring in:
  1. Pre-mRNA-splicing factor 38A
IPR045241
Domain description: WD repeat Prp46/PLRG1-like
Occurring in:
  1. Pleiotropic regulator 1
IPR012984
Domain description: PROCT domain
Occurring in:
  1. Pre-mRNA-processing-splicing factor 8
IPR037518
Domain description: MPN domain
Occurring in:
  1. Pre-mRNA-processing-splicing factor 8
IPR043173
Domain description: Prp8 RNase domain IV, fingers region
Occurring in:
  1. Pre-mRNA-processing-splicing factor 8
IPR043172
Domain description: Prp8 RNase domain IV, palm region
Occurring in:
  1. Pre-mRNA-processing-splicing factor 8
IPR019580
Domain description: Pre-mRNA-processing-splicing factor 8, U6-snRNA-binding
Occurring in:
  1. Pre-mRNA-processing-splicing factor 8
IPR019581
Domain description: Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding
Occurring in:
  1. Pre-mRNA-processing-splicing factor 8
IPR042516
Domain description: Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain superfamily
Occurring in:
  1. Pre-mRNA-processing-splicing factor 8
IPR019582
Domain description: RNA recognition motif, spliceosomal PrP8
Occurring in:
  1. Pre-mRNA-processing-splicing factor 8
IPR012592
Domain description: PROCN domain
Occurring in:
  1. Pre-mRNA-processing-splicing factor 8
IPR012591
Domain description: PRO8NT domain
Occurring in:
  1. Pre-mRNA-processing-splicing factor 8
IPR027652
Domain description: Pre-mRNA-processing-splicing factor 8
Occurring in:
  1. Pre-mRNA-processing-splicing factor 8
IPR032847
Domain description: Pre-mRNA-processing factor 17
Occurring in:
  1. Pre-mRNA-processing factor 17

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