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Human pre-Bact-2 spliceosome (SF3b/U2 snRNP portion)

Source organism: Homo sapiens
Biochemical function: protein binding
Biological process: mRNA processing
Cellular component: nucleoplasm

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GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00076
Domain description: RNA recognition motif
Occurring in:
  1. RNA-binding motif protein, X-linked 2
  2. Splicing factor 3B subunit 4
  3. Splicing factor 3B subunit 6
The deposited structure of PDB entry 7abh contains 2 copies of Pfam domain PF00076 (RNA recognition motif) in Splicing factor 3B subunit 4. Showing 2 copies in chain I [auth w] (some of the copies are out of the observed residue ranges!).
The deposited structure of PDB entry 7abh contains 1 copy of Pfam domain PF00076 (RNA recognition motif) in Splicing factor 3B subunit 6. Showing 1 copy in chain K [auth z].
The deposited structure of PDB entry 7abh contains 1 copy of Pfam domain PF00076 (RNA recognition motif) in RNA-binding motif protein, X-linked 2. Showing 1 copy in chain M [auth 1].

PF13921
Domain description: Myb-like DNA-binding domain
Occurring in:
  1. Cell division cycle 5-like protein
The deposited structure of PDB entry 7abh contains 2 copies of Pfam domain PF13921 (Myb-like DNA-binding domain) in Cell division cycle 5-like protein. Showing 2 copies in chain A [auth L] (some of the copies are out of the observed residue ranges!).

PF03660
Domain description: PHF5-like protein
Occurring in:
  1. PHD finger-like domain-containing protein 5A
The deposited structure of PDB entry 7abh contains 1 copy of Pfam domain PF03660 (PHF5-like protein) in PHD finger-like domain-containing protein 5A. Showing 1 copy in chain B [auth y].

PF07189
Domain description: Splicing factor 3B subunit 10 (SF3b10)
Occurring in:
  1. Splicing factor 3B subunit 5
The deposited structure of PDB entry 7abh contains 1 copy of Pfam domain PF07189 (Splicing factor 3B subunit 10 (SF3b10)) in Splicing factor 3B subunit 5. Showing 1 copy in chain J [auth x].

PF22646
Domain description: PPP2R1A-like HEAT repeat
Occurring in:
  1. Splicing factor 3B subunit 1

PF08920
Domain description: Splicing factor 3B subunit 1
Occurring in:
  1. Splicing factor 3B subunit 1
The deposited structure of PDB entry 7abh contains 1 copy of Pfam domain PF08920 (Splicing factor 3B subunit 1) in Splicing factor 3B subunit 1. Showing 1 copy in chain F [auth u].

PF01480
Domain description: PWI domain
Occurring in:
  1. Serine/arginine repetitive matrix protein 1
The deposited structure of PDB entry 7abh contains 1 copy of Pfam domain PF01480 (PWI domain) in Serine/arginine repetitive matrix protein 1. Showing 1 copy in chain N [auth Y].

PF04046
Domain description: PSP
Occurring in:
  1. Splicing factor 3B subunit 2
The deposited structure of PDB entry 7abh contains 1 copy of Pfam domain PF04046 (PSP) in Splicing factor 3B subunit 2. Showing 1 copy in chain G [auth T].

PF04037
Domain description: Domain of unknown function (DUF382)
Occurring in:
  1. Splicing factor 3B subunit 2
The deposited structure of PDB entry 7abh contains 1 copy of Pfam domain PF04037 (Domain of unknown function (DUF382) ) in Splicing factor 3B subunit 2. Showing 1 copy in chain G [auth T].

PF02037
Domain description: SAP domain
Occurring in:
  1. Splicing factor 3B subunit 2
The deposited structure of PDB entry 7abh contains 1 copy of Pfam domain PF02037 (SAP domain) in Splicing factor 3B subunit 2. Showing 1 copy in chain G [auth T] (this domain is out of the observed residue ranges!).

PF11831
Domain description: pre-mRNA splicing factor component
Occurring in:
  1. Cell division cycle 5-like protein
The deposited structure of PDB entry 7abh contains 1 copy of Pfam domain PF11831 (pre-mRNA splicing factor component) in Cell division cycle 5-like protein. Showing 1 copy in chain A [auth L] (this domain is out of the observed residue ranges!).

PF16835
Domain description: Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11)
Occurring in:
  1. Splicing factor 3A subunit 2
The deposited structure of PDB entry 7abh contains 1 copy of Pfam domain PF16835 (Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11)) in Splicing factor 3A subunit 2. Showing 1 copy in chain D [auth F] (this domain is out of the observed residue ranges!).

PF12874
Domain description: Zinc-finger of C2H2 type
Occurring in:
  1. Splicing factor 3A subunit 2
The deposited structure of PDB entry 7abh contains 1 copy of Pfam domain PF12874 (Zinc-finger of C2H2 type) in Splicing factor 3A subunit 2. Showing 1 copy in chain D [auth F].

PF03178
Domain description: CPSF A subunit region
Occurring in:
  1. Splicing factor 3B subunit 3
The deposited structure of PDB entry 7abh contains 1 copy of Pfam domain PF03178 (CPSF A subunit region) in Splicing factor 3B subunit 3. Showing 1 copy in chain H [auth E].

PF10433
Domain description: Mono-functional DNA-alkylating methyl methanesulfonate N-term
Occurring in:
  1. Splicing factor 3B subunit 3
The deposited structure of PDB entry 7abh contains 1 copy of Pfam domain PF10433 (Mono-functional DNA-alkylating methyl methanesulfonate N-term) in Splicing factor 3B subunit 3. Showing 1 copy in chain H [auth E].

PF18131
Domain description: KN17 SH3-like C-terminal domain
Occurring in:
  1. DNA/RNA-binding protein KIN17
The deposited structure of PDB entry 7abh contains 1 copy of Pfam domain PF18131 (KN17 SH3-like C-terminal domain) in DNA/RNA-binding protein KIN17. Showing 1 copy in chain P [auth 7] (this domain is out of the observed residue ranges!).

PF10357
Domain description: Domain of Kin17 curved DNA-binding protein
Occurring in:
  1. DNA/RNA-binding protein KIN17
The deposited structure of PDB entry 7abh contains 1 copy of Pfam domain PF10357 (Domain of Kin17 curved DNA-binding protein) in DNA/RNA-binding protein KIN17. Showing 1 copy in chain P [auth 7].

PF11931
Domain description: SF3a60/Prp9 C-terminal
Occurring in:
  1. Splicing factor 3A subunit 3
The deposited structure of PDB entry 7abh contains 1 copy of Pfam domain PF11931 (SF3a60/Prp9 C-terminal) in Splicing factor 3A subunit 3. Showing 1 copy in chain E [auth 4].

PF13297
Domain description: Replication stress response SDE2 C-terminal
Occurring in:
  1. Splicing factor 3A subunit 3
The deposited structure of PDB entry 7abh contains 1 copy of Pfam domain PF13297 (Replication stress response SDE2 C-terminal) in Splicing factor 3A subunit 3. Showing 1 copy in chain E [auth 4] (this domain is out of the observed residue ranges!).

PF16837
Domain description: Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9
Occurring in:
  1. Splicing factor 3A subunit 3
The deposited structure of PDB entry 7abh contains 1 copy of Pfam domain PF16837 (Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9) in Splicing factor 3A subunit 3. Showing 1 copy in chain E [auth 4] (this domain is out of the observed residue ranges!).

PF12108
Domain description: Splicing factor SF3a60 binding domain
Occurring in:
  1. Splicing factor 3A subunit 3
The deposited structure of PDB entry 7abh contains 1 copy of Pfam domain PF12108 (Splicing factor SF3a60 binding domain) in Splicing factor 3A subunit 3. Showing 1 copy in chain E [auth 4] (this domain is out of the observed residue ranges!).

PF00498
Domain description: FHA domain
Occurring in:
  1. Smad nuclear-interacting protein 1
The deposited structure of PDB entry 7abh contains 1 copy of Pfam domain PF00498 (FHA domain) in Smad nuclear-interacting protein 1. Showing 1 copy in chain L [auth 0].

Rfam RNA family (Rfam)
RF00004
Domain description: U2 spliceosomal RNA
Occurring in:
  1. U2 snRNA
The deposited structure of PDB entry 7abh contains 1 copy of Rfam domain RF00004 (U2 spliceosomal RNA) in U2 snRNA. Showing 1 copy in chain O [auth 2].

InterPro InterPro annotations
IPR000504
Domain description: RNA recognition motif domain
Occurring in:
  1. RNA-binding motif protein, X-linked 2
  2. Splicing factor 3B subunit 4
  3. Splicing factor 3B subunit 6
IPR001005
Domain description: SANT/Myb domain
Occurring in:
  1. Cell division cycle 5-like protein
IPR012677
Domain description: Nucleotide-binding alpha-beta plait domain superfamily
Occurring in:
  1. RNA-binding motif protein, X-linked 2
  2. Splicing factor 3B subunit 4
  3. Splicing factor 3B subunit 6
IPR002483
Domain description: PWI domain
Occurring in:
  1. Serine/arginine repetitive matrix protein 1
IPR015943
Domain description: WD40/YVTN repeat-like-containing domain superfamily
Occurring in:
  1. Splicing factor 3B subunit 3
IPR035979
Domain description: RNA-binding domain superfamily
Occurring in:
  1. RNA-binding motif protein, X-linked 2
  2. Splicing factor 3B subunit 4
  3. Splicing factor 3B subunit 6
IPR000253
Domain description: Forkhead-associated (FHA) domain
Occurring in:
  1. Smad nuclear-interacting protein 1
IPR005345
Domain description: PHF5-like
Occurring in:
  1. PHD finger-like domain-containing protein 5A
IPR009846
Domain description: Splicing factor 3B subunit 5/RDS3 complex subunit 10
Occurring in:
  1. Splicing factor 3B subunit 5
IPR011989
Domain description: Armadillo-like helical
Occurring in:
  1. Splicing factor 3B subunit 1
IPR006568
Domain description: PSP, proline-rich
Occurring in:
  1. Splicing factor 3B subunit 2
IPR003034
Domain description: SAP domain
Occurring in:
  1. Splicing factor 3B subunit 2
IPR017930
Domain description: Myb domain
Occurring in:
  1. Cell division cycle 5-like protein
IPR019447
Domain description: DNA/RNA-binding protein Kin17, WH-like domain
Occurring in:
  1. DNA/RNA-binding protein KIN17
IPR036236
Domain description: Zinc finger C2H2 superfamily
Occurring in:
  1. DNA/RNA-binding protein KIN17
  2. Splicing factor 3A subunit 2
IPR000690
Domain description: Matrin/U1-C, C2H2-type zinc finger
Occurring in:
  1. Splicing factor 3A subunit 3
  2. Splicing factor 3A subunit 2
IPR034150
Domain description: SF3B6, RNA recognition motif
Occurring in:
  1. Splicing factor 3B subunit 6
IPR017089
Domain description: Splicing factor 3B, subunit 5
Occurring in:
  1. Splicing factor 3B subunit 5
IPR034159
Domain description: SF3B4, RNA recognition motif 2
Occurring in:
  1. Splicing factor 3B subunit 4
IPR034158
Domain description: SF3B4, RNA recognition motif 1
Occurring in:
  1. Splicing factor 3B subunit 4
IPR016024
Domain description: Armadillo-type fold
Occurring in:
  1. Splicing factor 3B subunit 1
IPR015016
Domain description: Splicing factor 3B subunit 1
Occurring in:
  1. Splicing factor 3B subunit 1
IPR038737
Domain description: Splicing factor 3B subunit 1-like
Occurring in:
  1. Splicing factor 3B subunit 1
IPR036483
Domain description: PWI domain superfamily
Occurring in:
  1. Serine/arginine repetitive matrix protein 1
IPR007180
Domain description: Domain of unknown function DUF382
Occurring in:
  1. Splicing factor 3B subunit 2
IPR021786
Domain description: Pre-mRNA splicing factor component Cdc5p/Cef1, C-terminal
Occurring in:
  1. Cell division cycle 5-like protein
IPR047240
Domain description: Pre-mRNA splicing factor component CDC5L/Cef1, second SANT/myb-like domain
Occurring in:
  1. Cell division cycle 5-like protein
IPR009057
Domain description: Homedomain-like superfamily
Occurring in:
  1. Cell division cycle 5-like protein
IPR047242
Domain description: Pre-mRNA splicing factor component CDC5L/Cef1
Occurring in:
  1. Cell division cycle 5-like protein
IPR031781
Domain description: SF3A2 domain
Occurring in:
  1. Splicing factor 3A subunit 2
IPR003604
Domain description: Matrin/U1-C-like, C2H2-type zinc finger
Occurring in:
  1. Splicing factor 3A subunit 2
IPR004871
Domain description: Cleavage/polyadenylation specificity factor, A subunit, C-terminal
Occurring in:
  1. Splicing factor 3B subunit 3
IPR036322
Domain description: WD40-repeat-containing domain superfamily
Occurring in:
  1. Splicing factor 3B subunit 3
IPR018846
Domain description: RSE1/DDB1/CPSF1, first beta-propeller domain
Occurring in:
  1. Splicing factor 3B subunit 3
IPR041995
Domain description: Kin17, KOW domain
Occurring in:
  1. DNA/RNA-binding protein KIN17
IPR014722
Domain description: Large ribosomal subunit protein uL2, domain 2
Occurring in:
  1. DNA/RNA-binding protein KIN17
IPR041330
Domain description: KN17, SH3-like domain
Occurring in:
  1. DNA/RNA-binding protein KIN17
IPR038254
Domain description: DNA/RNA-binding protein KIN17, WH-like domain superfamily
Occurring in:
  1. DNA/RNA-binding protein KIN17
IPR037321
Domain description: KIN17-like protein
Occurring in:
  1. DNA/RNA-binding protein KIN17
IPR024598
Domain description: Splicing factor SF3a60 /Prp9 subunit, C-terminal
Occurring in:
  1. Splicing factor 3A subunit 3
IPR025086
Domain description: SDE2/SF3A3, SAP domain
Occurring in:
  1. Splicing factor 3A subunit 3
IPR031774
Domain description: SF3A3 domain
Occurring in:
  1. Splicing factor 3A subunit 3
IPR021966
Domain description: Splicing factor SF3a60 binding domain
Occurring in:
  1. Splicing factor 3A subunit 3
IPR045844
Domain description: Ist3-like, RNA recognition motif
Occurring in:
  1. RNA-binding motif protein, X-linked 2
IPR008984
Domain description: SMAD/FHA domain superfamily
Occurring in:
  1. Smad nuclear-interacting protein 1

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