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RUVBL1-RUVBL2 heterohexameric ring after binding of RNA helicase DHX34

Electron Microscopy
4.18Å resolution
PDB entry 7aho coloured by chain, front view.
PDB entry 7aho coloured by chain, side view.
PDB entry 7aho coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero hexamer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Nucleosome, Histone
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Multimeric state: hetero hexamer
Accessible surface area: 75495.21 Å2
Buried surface area: 23773.36 Å2
Dissociation area: 5,164.06 Å2
Dissociation energy (ΔGdiss): 33.82 kcal/mol
Dissociation entropy (TΔSdiss): 31.62 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-195084

Macromolecules

RuvB-like 1
Chains: A, B, C
Length: 476 amino acids
Theoretical weight: 52.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y265 (Residues: 1-456; Coverage: 100%)
Gene names: INO80H, NMP238, RUVBL1, TIP49, TIP49A
Pfam:
InterPro:
RuvB-like 1 in PDB entry 7aho, assembly 1, front view.
RuvB-like 1 in PDB entry 7aho, assembly 1, side view.
RuvB-like 1 in PDB entry 7aho, assembly 1, top view.
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RuvB-like 2
Chains: D, E, F
Length: 481 amino acids
Theoretical weight: 53.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y230 (Residues: 1-463; Coverage: 100%)
Gene names: CGI-46, INO80J, RUVBL2, TIP48, TIP49B
Pfam:
InterPro:
RuvB-like 2 in PDB entry 7aho, assembly 1, front view.
RuvB-like 2 in PDB entry 7aho, assembly 1, side view.
RuvB-like 2 in PDB entry 7aho, assembly 1, top view.
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