› 7ahu

X-ray diffraction
2.6Å resolution

Function and Biology Details

Reaction catalysed: 
Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin.
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-208306 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Anti-FX Fab of mim8 light chain Chains: A, L
Molecule details ›
Chains: A, L
Length: 216 amino acids
Theoretical weight: 23.72 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Anti-FX Fab of mim8 heavy chain Chains: B, H
Molecule details ›
Chains: B, H
Length: 222 amino acids
Theoretical weight: 24.03 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Activated factor Xa heavy chain Chains: C, E
Factor X light chain Chains: D, F

Ligands and Environments

2 bound ligands:
Ligand 0GJ 2 x 0GJ
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P21
Unit cell:
a: 63.13Å b: 105.25Å c: 145.78Å
α: 90° β: 89.995° γ: 90°
R-values:
R R work R free
0.214 0.203 0.263
Expression systems:
  • Homo sapiens
  • Escherichia coli

Quick links

Citations

8 review citations

Immunotherapeutic progress and application of bispecific antibody in cancer.
Kang et al. (2022)
7 more