› 7ahv

X-ray diffraction
3.11Å resolution

Function and Biology Details

Reaction catalysed: 
Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-208303 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
anti-FIXa Fab of mim8 heavy chain Chain: A
Molecule details ›
Chain: A
Length: 224 amino acids
Theoretical weight: 24.08 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
anti-FIXa Fab of mim8 light chain Chain: B
Molecule details ›
Chain: B
Length: 214 amino acids
Theoretical weight: 23.58 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Coagulation factor IXa light chain Chain: L
Coagulation factor IXa heavy chain Chain: H

Ligands and Environments

3 bound ligands:
Ligand SO4 17 x SO4
Ligand 0GJ 1 x 0GJ
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P4122
Unit cell:
a: 97.03Å b: 97.03Å c: 254.51Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.228 0.227 0.284
Expression systems:
  • Homo sapiens
  • Escherichia coli

Quick links

Citations

8 review citations

Immunotherapeutic progress and application of bispecific antibody in cancer.
Kang et al. (2022)
7 more

PDB-REDO

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