› 7akg

X-ray diffraction
2.08Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-522804 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase 17B Chain: A
Molecule details ›
Chain: A
Length: 327 amino acids
Theoretical weight: 37.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O94768 (Residues: 25-329; Coverage: 82%)
Gene names: DRAK2, STK17B
Sequence domains: Protein kinase domain

Ligands and Environments

2 bound ligands:
Ligand EDO 5 x EDO
Ligand 38O 1 x 38O
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P4122
Unit cell:
a: 84.289Å b: 84.289Å c: 114.17Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.187 0.186 0.219
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 citation in other articles

AD Informer Set: Chemical tools to facilitate Alzheimer's disease drug discovery.
Potjewyd et al. (2022)
5 more

3 mentions without citation

A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation.
Picado et al. (2020)
2 more