› › Function and Biology

Cryo-EM structure of Arabidopsis thaliana Complex-I (membrane core)

Source organism: Arabidopsis thaliana
Biochemical function: NADH dehydrogenase (ubiquinone) activity
Biological process: photorespiration
Cellular component: mitochondrion

Quick links

EC 7.1.1.2: NADH:ubiquinone reductase (H(+)-translocating)

Reaction catalysed:
NADH + ubiquinone + 5 H(+)(Side 1) = NAD(+) + ubiquinol + 4 H(+)(Side 2)
Systematic name:
NADH:ubiquinone oxidoreductase
Alternative Name(s):
  • Coenzyme Q reductase
  • Complex 1 dehydrogenase
  • Complex I (NADH:Q1 oxidoreductase)
  • Complex I (electron transport chain)
  • Complex I (mitochondrial electron transport)
  • DPNH-coenzyme Q reductase
  • DPNH-ubiquinone reductase
  • Dihydronicotinamide adenine dinucleotide-coenzyme Q reductase
  • Electron transfer complex I
  • Mitochondrial electron transport complex 1
  • Mitochondrial electron transport complex I
  • NADH coenzyme Q1 reductase
  • NADH dehydrogenase (ubiquinone)
  • NADH-CoQ oxidoreductase
  • NADH-CoQ reductase
  • NADH-Q6 oxidoreductase
  • NADH-coenzyme Q oxidoreductase
  • NADH-coenzyme Q reductase
  • NADH-ubiquinone oxidoreductase
  • NADH-ubiquinone reductase
  • NADH-ubiquinone-1 reductase
  • NADH:ubiquinone oxidoreductase complex
  • Reduced nicotinamide adenine dinucleotide-coenzyme Q reductase
  • Type 1 dehydrogenase
  • Ubiquinone reductase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00361
Domain description: Proton-conducting membrane transporter
Occurring in:
  1. NADH-ubiquinone oxidoreductase chain 5
  2. NADH-ubiquinone oxidoreductase chain 4
  3. NADH-ubiquinone oxidoreductase chain 2
The deposited structure of PDB entry 7aqq contains 1 copy of Pfam domain PF00361 (Proton-conducting membrane transporter) in NADH-ubiquinone oxidoreductase chain 5. Showing 1 copy in chain E [auth L] (this domain is out of the observed residue ranges!).
The deposited structure of PDB entry 7aqq contains 1 copy of Pfam domain PF00361 (Proton-conducting membrane transporter) in NADH-ubiquinone oxidoreductase chain 4. Showing 1 copy in chain F [auth M].
The deposited structure of PDB entry 7aqq contains 1 copy of Pfam domain PF00361 (Proton-conducting membrane transporter) in NADH-ubiquinone oxidoreductase chain 2. Showing 1 copy in chain G [auth N].

PF00132
Domain description: Bacterial transferase hexapeptide (six repeats)
Occurring in:
  1. Gamma carbonic anhydrase 2, mitochondrial

PF17250
Domain description: NADH-ubiquinone oxidoreductase 11 kDa subunit
Occurring in:
  1. F1N21.17
The deposited structure of PDB entry 7aqq contains 1 copy of Pfam domain PF17250 (NADH-ubiquinone oxidoreductase 11 kDa subunit) in NADH-ubiquinone oxidoreductase. Showing 1 copy in chain P [auth i].

PF10785
Domain description: NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit
Occurring in:
  1. NADH-ubiquinone oxidoreductase 21kDa subunit N-terminal domain-containing protein
The deposited structure of PDB entry 7aqq contains 1 copy of Pfam domain PF10785 (NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit) in NADH-ubiquinone oxidoreductase 21kDa subunit N-terminal domain-containing protein. Showing 1 copy in chain O [auth f].

PF10200
Domain description: NADH:ubiquinone oxidoreductase, NDUFS5-15kDa
Occurring in:
  1. NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-B
The deposited structure of PDB entry 7aqq contains 1 copy of Pfam domain PF10200 (NADH:ubiquinone oxidoreductase, NDUFS5-15kDa) in NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-B. Showing 1 copy in chain N [auth e].

PF15879
Domain description: NADH-ubiquinone oxidoreductase MWFE subunit
Occurring in:
  1. NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1
The deposited structure of PDB entry 7aqq contains 1 copy of Pfam domain PF15879 (NADH-ubiquinone oxidoreductase MWFE subunit) in NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1. Showing 1 copy in chain K [auth a].

PF06212
Domain description: GRIM-19 protein
Occurring in:
  1. NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13-A
The deposited structure of PDB entry 7aqq contains 1 copy of Pfam domain PF06212 (GRIM-19 protein) in NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13-A. Showing 1 copy in chain J [auth Z].

PF06747
Domain description: CHCH domain
Occurring in:
  1. NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8-B
The deposited structure of PDB entry 7aqq contains 1 copy of Pfam domain PF06747 (CHCH domain) in NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8-B. Showing 1 copy in chain I [auth X].

PF06455
Domain description: NADH dehydrogenase subunit 5 C-terminus
Occurring in:
  1. NADH-ubiquinone oxidoreductase chain 5
The deposited structure of PDB entry 7aqq contains 1 copy of Pfam domain PF06455 (NADH dehydrogenase subunit 5 C-terminus) in NADH-ubiquinone oxidoreductase chain 5. Showing 1 copy in chain E [auth L].

PF00662
Domain description: NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus
Occurring in:
  1. NADH-ubiquinone oxidoreductase chain 5
The deposited structure of PDB entry 7aqq contains 1 copy of Pfam domain PF00662 (NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus) in NADH-ubiquinone oxidoreductase chain 5. Showing 1 copy in chain E [auth L] (this domain is out of the observed residue ranges!).

PF00420
Domain description: NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
Occurring in:
  1. NADH-ubiquinone oxidoreductase chain 4L
The deposited structure of PDB entry 7aqq contains 1 copy of Pfam domain PF00420 (NADH-ubiquinone/plastoquinone oxidoreductase chain 4L) in NADH-ubiquinone oxidoreductase chain 4L. Showing 1 copy in chain D [auth K].

PF00499
Domain description: NADH-ubiquinone/plastoquinone oxidoreductase chain 6
Occurring in:
  1. NADH-ubiquinone oxidoreductase chain 6
The deposited structure of PDB entry 7aqq contains 1 copy of Pfam domain PF00499 (NADH-ubiquinone/plastoquinone oxidoreductase chain 6) in NADH-ubiquinone oxidoreductase chain 6. Showing 1 copy in chain C [auth J].

PF00146
Domain description: NADH dehydrogenase
Occurring in:
  1. NADH-ubiquinone oxidoreductase chain 1
The deposited structure of PDB entry 7aqq contains 1 copy of Pfam domain PF00146 (NADH dehydrogenase) in NADH-ubiquinone oxidoreductase chain 1. Showing 1 copy in chain B [auth H].

PF00507
Domain description: NADH-ubiquinone/plastoquinone oxidoreductase, chain 3
Occurring in:
  1. NADH-ubiquinone oxidoreductase chain 3
The deposited structure of PDB entry 7aqq contains 1 copy of Pfam domain PF00507 (NADH-ubiquinone/plastoquinone oxidoreductase, chain 3) in NADH-ubiquinone oxidoreductase chain 3. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR003918
Domain description: NADH:ubiquinone oxidoreductase
Occurring in:
  1. NADH-ubiquinone oxidoreductase chain 4
IPR047324
Domain description: Gamma carbonic anhydrase-like
Occurring in:
  1. Gamma carbonic anhydrase-like 2, mitochondrial
  2. Gamma carbonic anhydrase 2, mitochondrial
  3. Gamma carbonic anhydrase 1, mitochondrial
IPR011004
Domain description: Trimeric LpxA-like superfamily
Occurring in:
  1. Gamma carbonic anhydrase-like 2, mitochondrial
  2. Gamma carbonic anhydrase 2, mitochondrial
  3. Gamma carbonic anhydrase 1, mitochondrial
IPR001750
Domain description: NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit
Occurring in:
  1. NADH-ubiquinone oxidoreductase chain 5
  2. NADH-ubiquinone oxidoreductase chain 4
  3. NADH-ubiquinone oxidoreductase chain 2
IPR001694
Domain description: NADH:ubiquinone oxidoreductase, subunit 1/F420H2 oxidoreductase subunit H
Occurring in:
  1. NADH-ubiquinone oxidoreductase chain 1
IPR035204
Domain description: NADH-ubiquinone oxidoreductase 11kDa subunit
Occurring in:
  1. F1N21.17
IPR019342
Domain description: NADH:ubiquinone oxidoreductase, iron-sulphur subunit 5
Occurring in:
  1. NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-B
IPR017384
Domain description: NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex subunit 1
Occurring in:
  1. NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1
IPR009346
Domain description: GRIM-19
Occurring in:
  1. NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13-A
IPR010096
Domain description: NAD(P)H-quinone oxidoreductase, subunit N/subunit 2
Occurring in:
  1. NADH-ubiquinone oxidoreductase chain 2
IPR001133
Domain description: NADH-ubiquinone oxidoreductase chain 4L/K
Occurring in:
  1. NADH-ubiquinone oxidoreductase chain 4L
IPR018086
Domain description: NADH:ubiquinone oxidoreductase, subunit 1, conserved site
Occurring in:
  1. NADH-ubiquinone oxidoreductase chain 1
IPR000440
Domain description: NADH:ubiquinone/plastoquinone oxidoreductase, chain 3
Occurring in:
  1. NADH-ubiquinone oxidoreductase chain 3
IPR001451
Domain description: Hexapeptide repeat
Occurring in:
  1. Gamma carbonic anhydrase 2, mitochondrial
IPR045284
Domain description: At2g27730-like
Occurring in:
  1. Uncharacterized protein At2g27730, mitochondrial
IPR019721
Domain description: NADH-ubiquinone oxidoreductase, 21kDa subunit, N-terminal
Occurring in:
  1. NADH-ubiquinone oxidoreductase 21kDa subunit N-terminal domain-containing protein
IPR010625
Domain description: CHCH
Occurring in:
  1. NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8-B
IPR016680
Domain description: NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 8
Occurring in:
  1. NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8-B
IPR036010
Domain description: 2Fe-2S ferredoxin-like superfamily
Occurring in:
  1. F21O3.19 protein
IPR012675
Domain description: Beta-grasp domain superfamily
Occurring in:
  1. F21O3.19 protein
IPR001055
Domain description: Adrenodoxin-like
Occurring in:
  1. F21O3.19 protein
IPR010227
Domain description: NADH-quinone oxidoreductase, chain M/4
Occurring in:
  1. NADH-ubiquinone oxidoreductase chain 4
IPR010934
Domain description: NADH dehydrogenase subunit 5, C-terminal
Occurring in:
  1. NADH-ubiquinone oxidoreductase chain 5
IPR001516
Domain description: NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminal
Occurring in:
  1. NADH-ubiquinone oxidoreductase chain 5
IPR018393
Domain description: NADH-plastoquinone oxidoreductase, chain 5 subgroup
Occurring in:
  1. NADH-ubiquinone oxidoreductase chain 5
IPR003945
Domain description: NADH-quinone oxidoreductase, chain 5-like
Occurring in:
  1. NADH-ubiquinone oxidoreductase chain 5
IPR039428
Domain description: NADH-ubiquinone oxidoreductase chain 4L/Mnh complex subunit C1-like
Occurring in:
  1. NADH-ubiquinone oxidoreductase chain 4L
IPR001457
Domain description: NADH:ubiquinone/plastoquinone oxidoreductase, chain 6
Occurring in:
  1. NADH-ubiquinone oxidoreductase chain 6
IPR042106
Domain description: NADH-ubiquinone/plastoquinone oxidoreductase chain 6, subunit NuoJ
Occurring in:
  1. NADH-ubiquinone oxidoreductase chain 6
IPR038430
Domain description: NADH:ubiquinone oxidoreductase, subunit 3 superfamily
Occurring in:
  1. NADH-ubiquinone oxidoreductase chain 3
IPR023043
Domain description: NAD(P)H-quinone oxidoreductase subunit 3, bacterial/plastid
Occurring in:
  1. NADH-ubiquinone oxidoreductase chain 3

Quick links