› 7axz

Electron Microscopy
3.2Å resolution

Ku70/80 complex apo form

Released:
DOI: 10.2210/pdb7axz/pdb
PDB entry 7axz coloured by chain, front view.
PDB entry 7axz coloured by chain, side view.
PDB entry 7axz coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
SAP domain forms a flexible part of DNA aperture in Ku70/80.
Hnízda A, Tesina P, Nguyen TB, Kukačka Z, Kater L, Chaplin AK, Beckmann R, Ascher DB, Novák P, Blundell TL
OpenAccess logo FEBS J 288 4382-4393 (2021)
PMID: 33511782
Related structures: EMD-11933

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146401 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
X-ray repair cross-complementing protein 6 Chain: A
Molecule details ›
Chain: A
Length: 609 amino acids
Theoretical weight: 69.95 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P12956 (Residues: 1-609; Coverage: 100%)
Gene names: G22P1, XRCC6
Sequence domains:
X-ray repair cross-complementing protein 5 Chain: B
Molecule details ›
Chain: B
Length: 732 amino acids
Theoretical weight: 82.81 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P13010 (Residues: 1-732; Coverage: 100%)
Gene names: G22P2, XRCC5
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.2Å
Relevant EMDB volumes: EMD-11933
Expression system: Spodoptera frugiperda

Quick links

Citations

3 review citations

Double-strand DNA break repair: molecular mechanisms and therapeutic targets.
Tan et al. (2023)
2 more

1 mention without citation

SAP domain forms a flexible part of DNA aperture in Ku70/80.
Hnízda et al. (2021)