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Cryo-EM structure of USP1-UAF1 bound to mono-ubiquitinated FANCD2, and FANCI

Source organism: Homo sapiens
Biochemical function: protein binding
Biological process: DNA repair
Cellular component: cytosol

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EC 3.4.19.12: Ubiquitinyl hydrolase 1

Reaction catalysed:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Systematic name:
-
Alternative Name(s):
  • Ubiquitin C-terminal hydrolase
  • Ubiquitin carboxyl-terminal hydrolase
  • Ubiquitin thiolesterase
  • Yeast ubiquitin hydrolase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00400
Domain description: WD domain, G-beta repeat
Occurring in:
  1. WD repeat-containing protein 48
The deposited structure of PDB entry 7ay1 contains 6 copies of Pfam domain PF00400 (WD domain, G-beta repeat) in WD repeat-containing protein 48. Showing 6 copies in chain E.

PF11816
Domain description: Domain of unknown function (DUF3337)
Occurring in:
  1. WD repeat-containing protein 48
The deposited structure of PDB entry 7ay1 contains 1 copy of Pfam domain PF11816 (Domain of unknown function (DUF3337)) in WD repeat-containing protein 48. Showing 1 copy in chain E.

PF00443
Domain description: Ubiquitin carboxyl-terminal hydrolase
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase 1
The deposited structure of PDB entry 7ay1 contains 1 copy of Pfam domain PF00443 (Ubiquitin carboxyl-terminal hydrolase) in Ubiquitin carboxyl-terminal hydrolase 1. Showing 1 copy in chain D.

PF00240
Domain description: Ubiquitin family
Occurring in:
  1. Ubiquitin
The deposited structure of PDB entry 7ay1 contains 1 copy of Pfam domain PF00240 (Ubiquitin family) in Ubiquitin. Showing 1 copy in chain C.

PF14631
Domain description: Fanconi anaemia protein FancD2 nuclease
Occurring in:
  1. Fanconi anemia group D2 protein
The deposited structure of PDB entry 7ay1 contains 1 copy of Pfam domain PF14631 (Fanconi anaemia protein FancD2 nuclease) in Fanconi anemia group D2 protein. Showing 1 copy in chain B.

PF14678
Domain description: FANCI solenoid 4
Occurring in:
  1. Fanconi anemia group I protein
The deposited structure of PDB entry 7ay1 contains 1 copy of Pfam domain PF14678 (FANCI solenoid 4) in Fanconi anemia group I protein. Showing 1 copy in chain A.

PF14677
Domain description: FANCI solenoid 3
Occurring in:
  1. Fanconi anemia group I protein
The deposited structure of PDB entry 7ay1 contains 1 copy of Pfam domain PF14677 (FANCI solenoid 3) in Fanconi anemia group I protein. Showing 1 copy in chain A.

PF14680
Domain description: FANCI helical domain 2
Occurring in:
  1. Fanconi anemia group I protein
The deposited structure of PDB entry 7ay1 contains 1 copy of Pfam domain PF14680 (FANCI helical domain 2) in Fanconi anemia group I protein. Showing 1 copy in chain A.

PF14676
Domain description: FANCI solenoid 2
Occurring in:
  1. Fanconi anemia group I protein
The deposited structure of PDB entry 7ay1 contains 1 copy of Pfam domain PF14676 (FANCI solenoid 2) in Fanconi anemia group I protein. Showing 1 copy in chain A.

PF14679
Domain description: FANCI helical domain 1
Occurring in:
  1. Fanconi anemia group I protein
The deposited structure of PDB entry 7ay1 contains 1 copy of Pfam domain PF14679 (FANCI helical domain 1) in Fanconi anemia group I protein. Showing 1 copy in chain A.

PF14675
Domain description: FANCI solenoid 1
Occurring in:
  1. Fanconi anemia group I protein
The deposited structure of PDB entry 7ay1 contains 1 copy of Pfam domain PF14675 (FANCI solenoid 1) in Fanconi anemia group I protein. Showing 1 copy in chain A.

PF14674
Domain description: FANCI solenoid 1 cap
Occurring in:
  1. Fanconi anemia group I protein
The deposited structure of PDB entry 7ay1 contains 1 copy of Pfam domain PF14674 (FANCI solenoid 1 cap) in Fanconi anemia group I protein. Showing 1 copy in chain A (this domain is out of the observed residue ranges!).

InterPro InterPro annotations
IPR001680
Domain description: WD40 repeat
Occurring in:
  1. WD repeat-containing protein 48
IPR020472
Domain description: G-protein beta WD-40 repeat
Occurring in:
  1. WD repeat-containing protein 48
IPR019956
Domain description: Ubiquitin domain
Occurring in:
  1. Ubiquitin
IPR000626
Domain description: Ubiquitin-like domain
Occurring in:
  1. Ubiquitin
IPR029448
Domain description: Fanconi anaemia protein FANCD2
Occurring in:
  1. Fanconi anemia group D2 protein
IPR015943
Domain description: WD40/YVTN repeat-like-containing domain superfamily
Occurring in:
  1. WD repeat-containing protein 48
IPR001394
Domain description: Peptidase C19, ubiquitin carboxyl-terminal hydrolase
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase 1
IPR026171
Domain description: Fanconi anemia group I protein
Occurring in:
  1. Fanconi anemia group I protein
IPR021772
Domain description: WDR48/Bun107
Occurring in:
  1. WD repeat-containing protein 48
IPR019775
Domain description: WD40 repeat, conserved site
Occurring in:
  1. WD repeat-containing protein 48
IPR036322
Domain description: WD40-repeat-containing domain superfamily
Occurring in:
  1. WD repeat-containing protein 48
IPR018200
Domain description: Ubiquitin specific protease, conserved site
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase 1
IPR033815
Domain description: Ubiquitin specific peptidase 1
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase 1
IPR028889
Domain description: Ubiquitin specific protease domain
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase 1
IPR038765
Domain description: Papain-like cysteine peptidase superfamily
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase 1
IPR019954
Domain description: Ubiquitin conserved site
Occurring in:
  1. Ubiquitin
IPR029071
Domain description: Ubiquitin-like domain superfamily
Occurring in:
  1. Ubiquitin
IPR029314
Domain description: FANCI solenoid 4 domain
Occurring in:
  1. Fanconi anemia group I protein
IPR029313
Domain description: FANCI solenoid 3 domain
Occurring in:
  1. Fanconi anemia group I protein
IPR029312
Domain description: FANCI helical domain 2
Occurring in:
  1. Fanconi anemia group I protein
IPR029315
Domain description: FANCI solenoid 2 domain
Occurring in:
  1. Fanconi anemia group I protein
IPR029310
Domain description: FANCI helical domain 1
Occurring in:
  1. Fanconi anemia group I protein
IPR029308
Domain description: FANCI solenoid 1 domain
Occurring in:
  1. Fanconi anemia group I protein
IPR029305
Domain description: FANCI solenoid 1 cap
Occurring in:
  1. Fanconi anemia group I protein

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