PDB 7b0n structure summary ‹ Protein Data Bank in Europe (PDBe)

Function and Biology Details

Reaction catalysed:

NADH + ubiquinone + 5 H(+)(Side 1) = NAD(+) + ubiquinol + 4 H(+)(Side 2)

Biochemical function:

oxidoreductase activity

Biological process:

proton transmembrane transport

Cellular component:

mitochondrion

Sequence domains:

70 more domains

Structure analysis Details

Assembly composition:

hetero 42-mer (preferred)

PDBe Complex ID:

PDB-CPX-103381 (preferred)

Entry contents:

42 distinct polypeptide molecules

Macromolecules (42 distinct):

NADH-ubiquinone oxidoreductase chain 3 Chain: A

Molecule details ›

Chain: A
Length: 128 amino acids
Theoretical weight: 14.51 KDa
Source organism: Yarrowia lipolytica
Expression system: Yarrowia lipolytica
UniProt:

Canonical: S5TMS4 (Residues: 1-128; Coverage: 100%)

Gene names: YALI1_M00472r, nad3
Sequence domains: NADH-ubiquinone/plastoquinone oxidoreductase, chain 3

NADH:ubiquinone oxidoreductase-like 20kDa subunit domain-containing protein Chain: B

Molecule details ›

Chain: B
Length: 210 amino acids
Theoretical weight: 23.46 KDa
Source organism: Yarrowia lipolytica
Expression system: Yarrowia lipolytica
UniProt:

Canonical: Q9UUT7 (Residues: 1-210; Coverage: 100%)

Gene names: B0I71DRAFT_136033, YALI1_F09003g, nukm
Sequence domains: NADH ubiquinone oxidoreductase, 20 Kd subunit

NADH:ubiquinone oxidoreductase 30kDa subunit domain-containing protein Chain: C

Molecule details ›

Chain: C
Length: 293 amino acids
Theoretical weight: 33.64 KDa
Source organism: Yarrowia lipolytica
Expression system: Yarrowia lipolytica
UniProt:

Canonical: Q9UUU0 (Residues: 1-281; Coverage: 100%)

Gene names: B0I71DRAFT_126141, nugm
Sequence domains: Respiratory-chain NADH dehydrogenase, 30 Kd subunit

NADH-quinone oxidoreductase subunit D domain-containing protein Chain: D

Molecule details ›

Chain: D
Length: 466 amino acids
Theoretical weight: 52.47 KDa
Source organism: Yarrowia lipolytica
Expression system: Yarrowia lipolytica
UniProt:

Canonical: Q9UUU1 (Residues: 1-466; Coverage: 100%)

Gene names: B0I71DRAFT_131656, YALI1_F22993g, nucm
Sequence domains: Respiratory-chain NADH dehydrogenase, 49 Kd subunit

Subunit NUHM of protein NADH:Ubiquinone Oxidoreductase (Complex I) Chain: E

Molecule details ›

Chain: E
Length: 243 amino acids
Theoretical weight: 27.25 KDa
Source organism: Yarrowia lipolytica
Expression system: Yarrowia lipolytica
UniProt:

Canonical: Q9UUT9 (Residues: 1-243; Coverage: 100%)

Gene names: B0I71DRAFT_136742, nuhm
Sequence domains: Thioredoxin-like [2Fe-2S] ferredoxin

NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial Chain: F

Molecule details ›

Chain: F
Length: 488 amino acids
Theoretical weight: 53.83 KDa
Source organism: Yarrowia lipolytica
Expression system: Yarrowia lipolytica
UniProt:

Canonical: Q9UUU2 (Residues: 1-488; Coverage: 100%)

Gene names: NUO51, YALI1_B26679g, nubm
Sequence domains:

NUAM protein Chain: G

Molecule details ›

Chain: G
Length: 728 amino acids
Theoretical weight: 79.09 KDa
Source organism: Yarrowia lipolytica
Expression system: Yarrowia lipolytica
UniProt:

Canonical: Q9UUU3 (Residues: 1-728; Coverage: 100%)

Gene names: B0I71DRAFT_14167, YALI1_D07089g, nuam
Sequence domains:

NADH-ubiquinone oxidoreductase chain 1 Chain: H

Molecule details ›

Chain: H
Length: 341 amino acids
Theoretical weight: 38.39 KDa
Source organism: Yarrowia lipolytica
Expression system: Yarrowia lipolytica
UniProt:

Canonical: S5U3V2 (Residues: 1-341; Coverage: 100%)

Gene names: YALI1_M00064g, nad1
Sequence domains: NADH dehydrogenase

4Fe-4S ferredoxin-type domain-containing protein Chain: I

Molecule details ›

Chain: I
Length: 193 amino acids
Theoretical weight: 21.89 KDa
Source organism: Yarrowia lipolytica
Expression system: Yarrowia lipolytica
UniProt:

Canonical: Q9UUT8 (Residues: 37-229; Coverage: 84%)

Gene names: B0I71DRAFT_132693, YALI1_F01456g, nuim
Sequence domains: 4Fe-4S dicluster domain

NADH-ubiquinone oxidoreductase chain 6 Chain: J

Molecule details ›

Chain: J
Length: 185 amino acids
Theoretical weight: 20.79 KDa
Source organism: Yarrowia lipolytica
Expression system: Yarrowia lipolytica
UniProt:

Canonical: S5U3X7 (Residues: 1-184; Coverage: 100%)

Gene names: YALI1_M00056g, nad6
Sequence domains: NADH-ubiquinone/plastoquinone oxidoreductase chain 6

NADH-ubiquinone oxidoreductase chain 4L Chain: K

Molecule details ›

Chain: K
Length: 89 amino acids
Theoretical weight: 9.84 KDa
Source organism: Yarrowia lipolytica
Expression system: Yarrowia lipolytica
UniProt:

Canonical: S5U4U1 (Residues: 1-89; Coverage: 100%)

Gene names: YALI1_M00335g, nad4L
Sequence domains: NADH-ubiquinone/plastoquinone oxidoreductase chain 4L

NADH-ubiquinone oxidoreductase chain 5 Chain: L

Molecule details ›

Chain: L
Length: 655 amino acids
Theoretical weight: 73.77 KDa
Source organism: Yarrowia lipolytica
Expression system: Yarrowia lipolytica
UniProt:

Canonical: S5TF58 (Residues: 1-655; Coverage: 100%)

Gene names: YALI1_M00338r, nad5
Sequence domains:

NADH-ubiquinone oxidoreductase chain 4 Chain: M

Molecule details ›

Chain: M
Length: 486 amino acids
Theoretical weight: 54.53 KDa
Source organism: Yarrowia lipolytica
Expression system: Yarrowia lipolytica
UniProt:

Canonical: S5TMP9 (Residues: 1-486; Coverage: 100%)

Gene names: YALI1_M00296g, nad4
Sequence domains: Proton-conducting membrane transporter

NADH-ubiquinone oxidoreductase chain 2 Chain: N

Molecule details ›

Chain: N
Length: 469 amino acids
Theoretical weight: 53.38 KDa
Source organism: Yarrowia lipolytica
Expression system: Yarrowia lipolytica
UniProt:

Canonical: S5U4R9 (Residues: 1-469; Coverage: 100%)

Gene names: YALI1_M00458g, nad2
Sequence domains: Proton-conducting membrane transporter

NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit-domain-containing protein Chain: O

Molecule details ›

Chain: O
Length: 169 amino acids
Theoretical weight: 18.59 KDa
Source organism: Yarrowia lipolytica
Expression system: Yarrowia lipolytica
UniProt:

Canonical: A0A1D8NKB4 (Residues: 1-169; Coverage: 100%)

Gene names: B0I71DRAFT_128923, YALI1_E33570g
Sequence domains:

NAD-dependent epimerase/dehydratase domain-containing protein Chain: P

Molecule details ›

Chain: P
Length: 355 amino acids
Theoretical weight: 40.49 KDa
Source organism: Yarrowia lipolytica
Expression system: Yarrowia lipolytica
UniProt:

Canonical: A0A371BY45 (Residues: 21-375; Coverage: 95%)

Gene name: B0I71DRAFT_137087
Sequence domains: NAD dependent epimerase/dehydratase family

NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial Chain: Q

Molecule details ›

Chain: Q
Length: 161 amino acids
Theoretical weight: 18.66 KDa
Source organism: Yarrowia lipolytica
Expression system: Yarrowia lipolytica
UniProt:

Canonical: A0A1D8N7X0 (Residues: 1-161; Coverage: 100%)

Gene names: B0I71DRAFT_135289, YALI1_B19507g
Sequence domains: NADH dehydrogenase ubiquinone Fe-S protein 4

Zinc finger CHCC-type domain-containing protein Chain: R

Molecule details ›

Chain: R
Length: 118 amino acids
Theoretical weight: 13.13 KDa
Source organism: Yarrowia lipolytica
Expression system: Yarrowia lipolytica
UniProt:

Canonical: A0A1H6Q8Z5 (Residues: 19-136; Coverage: 87%)

Gene names: B0I71DRAFT_130567, YALI1_D24109g
Sequence domains: Zinc-finger domain

Ribosomal protein/NADH dehydrogenase domain-containing protein Chain: S

Molecule details ›

Chain: S
Length: 87 amino acids
Theoretical weight: 9.62 KDa
Source organism: Yarrowia lipolytica
Expression system: Yarrowia lipolytica
UniProt:

Canonical: A0A1H6PJS3 (Residues: 1-87; Coverage: 100%)

Gene names: B0I71DRAFT_160608, YALI1_C04281g
Sequence domains: Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain

Acyl carrier protein Chain: T

Molecule details ›

Chain: T
Length: 81 amino acids
Theoretical weight: 8.82 KDa
Source organism: Yarrowia lipolytica
Expression system: Yarrowia lipolytica
UniProt:

Canonical: A0A1H6PXT9 (Residues: 29-109; Coverage: 74%)

Gene names: B0I71DRAFT_165126, YALI1_D18037g
Sequence domains: Phosphopantetheine attachment site

Acyl carrier protein Chain: U

Molecule details ›

Chain: U
Length: 88 amino acids
Theoretical weight: 9.53 KDa
Source organism: Yarrowia lipolytica
Expression system: Yarrowia lipolytica
UniProt:

Canonical: A0A1D8NG21 (Residues: 45-132; Coverage: 67%)

Gene name: YALI1_D32594g
Sequence domains: Phosphopantetheine attachment site

ETC complex I subunit conserved region-domain-containing protein Chain: V

Molecule details ›

Chain: V
Length: 144 amino acids
Theoretical weight: 16.66 KDa
Source organism: Yarrowia lipolytica
Expression system: Yarrowia lipolytica
UniProt:

Canonical: A0A371C5F3 (Residues: 1-144; Coverage: 100%)

Gene name: B0I71DRAFT_119420
Sequence domains: ETC complex I subunit conserved region

Complex 1 LYR protein domain-containing protein Chain: W

Molecule details ›

Chain: W
Length: 124 amino acids
Theoretical weight: 14.78 KDa
Source organism: Yarrowia lipolytica
Expression system: Yarrowia lipolytica
UniProt:

Canonical: A0A1D8N3C8 (Residues: 1-124; Coverage: 100%)

Gene names: B0I71DRAFT_136559, YALI1_A01824g
Sequence domains: Complex 1 protein (LYR family)

NADH-ubiquinone oxidoreductase Chain: X

Molecule details ›

Chain: X
Length: 172 amino acids
Theoretical weight: 19.36 KDa
Source organism: Yarrowia lipolytica
Expression system: Yarrowia lipolytica
UniProt:

Canonical: A0A371C2D0 (Residues: 1-172; Coverage: 100%)

Gene name: B0I71DRAFT_134276
Sequence domains: CHCH domain

Complex I-B14.7 Chain: Y

Molecule details ›

Chain: Y
Length: 180 amino acids
Theoretical weight: 18.97 KDa
Source organism: Yarrowia lipolytica
Expression system: Yarrowia lipolytica
UniProt:

Canonical: A0A371CB65 (Residues: 19-198; Coverage: 91%)

Gene name: B0I71DRAFT_129038

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 Chain: Z

Molecule details ›

Chain: Z
Length: 122 amino acids
Theoretical weight: 13.98 KDa
Source organism: Yarrowia lipolytica
Expression system: Yarrowia lipolytica
UniProt:

Canonical: A0A1H6PPE5 (Residues: 2-123; Coverage: 99%)

Gene names: B0I71DRAFT_132113, YALI1_E34222g
Sequence domains: GRIM-19 protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 Chain: a

Molecule details ›

Chain: a
Length: 86 amino acids
Theoretical weight: 9.68 KDa
Source organism: Yarrowia lipolytica
Expression system: Yarrowia lipolytica
UniProt:

Canonical: A0A1D8NC63 (Residues: 2-87; Coverage: 99%)

Gene names: B0I71DRAFT_173710, YALI1_C30086g
Sequence domains: NADH-ubiquinone oxidoreductase MWFE subunit

subunit NI9M of protein NADH:Ubiquinone Oxidoreductase (Complex I) Chain: b

Molecule details ›

Chain: b
Length: 78 amino acids
Theoretical weight: 8.99 KDa
Source organism: Yarrowia lipolytica
Expression system: Yarrowia lipolytica
UniProt:

Canonical: A0A1D8NJR0 (Residues: 1-78; Coverage: 100%)

Gene names: B0I71DRAFT_131413, YALI1_E28107g

Subunit NUZM of NADH:Ubiquinone Oxidoreductase (Complex I) Chain: c

Molecule details ›

Chain: c
Length: 182 amino acids
Theoretical weight: 19.77 KDa
Source organism: Yarrowia lipolytica
Expression system: Yarrowia lipolytica
UniProt:

Canonical: A0A1D8N3H5 (Residues: 1-182; Coverage: 100%)

Gene names: B0I71DRAFT_129288, YALI1_A03153g

subunit NEBM of protein NADH:Ubiquinone Oxidoreductase (Complex I) [Yarrowia lipolytica] Chain: d

Molecule details ›

Chain: d
Length: 73 amino acids
Theoretical weight: 7.93 KDa
Source organism: Yarrowia lipolytica
Expression system: Yarrowia lipolytica
UniProt:

Canonical: A0A1D8NGI5 (Residues: 2-74; Coverage: 99%)

Gene name: YALI1_E00527g

Subunit NIPM of NADH:Ubiquinone Oxidoreductase (Complex I) Chain: e

Molecule details ›

Chain: e
Length: 89 amino acids
Theoretical weight: 10.04 KDa
Source organism: Yarrowia lipolytica
Expression system: Yarrowia lipolytica
UniProt:

Canonical: A0A1D8NNZ0 (Residues: 1-89; Coverage: 100%)

Gene names: B0I71DRAFT_135789, YALI1_F24343g
Sequence domains: NADH:ubiquinone oxidoreductase, NDUFS5-15kDa

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit Chain: f

Molecule details ›

Chain: f
Length: 138 amino acids
Theoretical weight: 16.18 KDa
Source organism: Yarrowia lipolytica
Expression system: Yarrowia lipolytica
UniProt:

Canonical: A0A1D8N5V2 (Residues: 1-138; Coverage: 100%)

Gene names: B0I71DRAFT_100046, YALI1_B00908g
Sequence domains: NADH ubiquinone oxidoreductase subunit NDUFA12

NUWM protein Chain: g

Molecule details ›

Chain: g
Length: 249 amino acids
Theoretical weight: 28.48 KDa
Source organism: Yarrowia lipolytica
Expression system: Yarrowia lipolytica
UniProt:

Canonical: Q6ZY23 (Residues: 1-249; Coverage: 100%)

Gene names: B0I71DRAFT_98177, YALI1_E34367g, nuwm

subunit NUNM of protein NADH:Ubiquinone Oxidoreductase (Complex I) Chain: h

Molecule details ›

Chain: h
Length: 139 amino acids
Theoretical weight: 15.82 KDa
Source organism: Yarrowia lipolytica
Expression system: Yarrowia lipolytica
UniProt:

Canonical: A0A371CFV9 (Residues: 1-139; Coverage: 100%)

Gene name: B0I71DRAFT_126580

Subunit NUUM of NADH:Ubiquinone Oxidoreductase (Complex I) Chain: i

Molecule details ›

Chain: i
Length: 90 amino acids
Theoretical weight: 9.79 KDa
Source organism: Yarrowia lipolytica
Expression system: Yarrowia lipolytica
UniProt:

Canonical: A0A1H6Q311 (Residues: 1-90; Coverage: 100%)

Gene names: B0I71DRAFT_133979, YALI1_D22691g

Subunit NUVM of NADH:Ubiquinone Oxidoreductase (Complex I) Chain: j

Molecule details ›

Chain: j
Length: 67 amino acids
Theoretical weight: 7.81 KDa
Source organism: Yarrowia lipolytica
Expression system: Yarrowia lipolytica
UniProt:

Canonical: A0A1D8NFX6 (Residues: 1-67; Coverage: 100%)

Gene names: B0I71DRAFT_129560, YALI1_D30003g

NADH dehydrogenase 1 beta subcomplex subunit 3 Chain: k

Molecule details ›

Chain: k
Length: 60 amino acids
Theoretical weight: 6.95 KDa
Source organism: Yarrowia lipolytica
Expression system: Yarrowia lipolytica
UniProt:

Canonical: A0A371C0F2 (Residues: 1-60; Coverage: 100%)

Gene name: B0I71DRAFT_135324
Sequence domains: NADH-ubiquinone oxidoreductase B12 subunit family

Subunit NIAM of NADH:Ubiquinone Oxidoreductase (Complex I) Chain: l

Molecule details ›

Chain: l
Length: 149 amino acids
Theoretical weight: 17.33 KDa
Source organism: Yarrowia lipolytica
Expression system: Yarrowia lipolytica
UniProt:

Canonical: A0A1D8ND94 (Residues: 1-149; Coverage: 100%)

Gene names: B0I71DRAFT_129122, YALI1_D06302g
Sequence domains: NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8)

NUVM protein Chain: m

Molecule details ›

Chain: m
Length: 93 amino acids
Theoretical weight: 10.49 KDa
Source organism: Yarrowia lipolytica
Expression system: Yarrowia lipolytica
UniProt:

Canonical: Q6ZY24 (Residues: 1-93; Coverage: 100%)

Gene names: B0I71DRAFT_136036, YALI1_F09017g, nuvm

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 Chain: n

Molecule details ›

Chain: n
Length: 109 amino acids
Theoretical weight: 12.9 KDa
Source organism: Yarrowia lipolytica
Expression system: Yarrowia lipolytica
UniProt:

Canonical: A0A1D8NDL1 (Residues: 1-109; Coverage: 100%)

Gene names: B0I71DRAFT_130937, YALI1_D09203g

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 Chain: o

Molecule details ›

Chain: o
Length: 99 amino acids
Theoretical weight: 11.22 KDa
Source organism: Yarrowia lipolytica
Expression system: Yarrowia lipolytica
UniProt:

Canonical: A0A1H6PKH9 (Residues: 1-99; Coverage: 100%)

Gene names: B0I71DRAFT_134867, YALI1_E37603g
Sequence domains: NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7)

Subunit NIDM of NADH:Ubiquinone Oxidoreductase (Complex I) Chain: p

Molecule details ›

Chain: p
Length: 92 amino acids
Theoretical weight: 11.04 KDa
Source organism: Yarrowia lipolytica
Expression system: Yarrowia lipolytica
UniProt: