› 7b10

X-ray diffraction
1.92Å resolution

Crystal structure of MLLT1 YEATS domain T1 mutant in complex with benzimidazole-amide based compound 1

Released:
DOI: 10.2210/pdb7b10/pdb
PDB entry 7b10 coloured by chain, front view.
PDB entry 7b10 coloured by chain, side view.
PDB entry 7b10 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure and Inhibitor Binding Characterization of Oncogenic MLLT1 Mutants.
Ni X, Londregan AT, Owen DR, Knapp S, Chaikuad A
ACS Chem Biol 16 571-578 (2021)
PMID: 33749253

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169829 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein ENL Chain: A
Molecule details ›
Chain: A
Length: 157 amino acids
Theoretical weight: 18.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q03111 (Residues: 1-114, 115-148; Coverage: 27%)
Gene names: ENL, LTG19, MLLT1, YEATS1
Sequence domains: YEATS family

Ligands and Environments

3 bound ligands:
Ligand GKT 1 x GKT
Ligand IOD 1 x IOD
Ligand EDO 11 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: C2
Unit cell:
a: 91.111Å b: 39.357Å c: 53.111Å
α: 90° β: 125.58° γ: 90°
R-values:
R R work R free
0.175 0.174 0.209
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 citation in other articles

Hotspot mutations in the structured ENL YEATS domain link aberrant transcriptional condensates and cancer.
Song et al. (2022)
1 more

4 mentions without citation

Microbial diversity in Maras salterns, a hypersaline environment in the Peruvian Andes.
Maturrano et al. (2006)
3 more