› 7b3w

X-ray diffraction
2.02Å resolution

Crystal structure of c-MET bound by compound 4

Released:
DOI: 10.2210/pdb7b3w/pdb
PDB entry 7b3w coloured by chain, front view.
PDB entry 7b3w coloured by chain, side view.
PDB entry 7b3w coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural Basis for Targeting the Folded P-Loop Conformation of c-MET.
Collie GW, Michaelides IN, Embrey K, Stubbs CJ, Börjesson U, Dale IL, Snijder A, Barlind L, Song K, Khurana P, Phillips C, Storer RI
OpenAccess logo ACS Med Chem Lett 12 162-167 (2021)
PMID: 33488978

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-530690 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hepatocyte growth factor receptor Chain: A
Molecule details ›
Chain: A
Length: 299 amino acids
Theoretical weight: 33.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P08581 (Residues: 1049-1346; Coverage: 22%)
Gene name: MET
Sequence domains: Protein tyrosine and serine/threonine kinase

Ligands and Environments

2 bound ligands:
Ligand EDO 1 x EDO
Ligand SVH 1 x SVH
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P41212
Unit cell:
a: 66.82Å b: 66.82Å c: 188.63Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.234 0.232 0.261
Expression system: Escherichia coli

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Citations

1 review citation

The Recycling of Substandard Rocket Fuel N,N-Dimethylhydrazine via the Involvement of Its Hydrazones Derived from Glyoxal, Acrolein, Metacrolein, Crotonaldehyde, and Formaldehyde in Organic Synthesis.
Ivanova et al. (2023)
5 other articles

1 mention without citation

Repurposing Synthetic Congeners of a Natural Product Aurone Unveils a Lead Antitumor Agent Inhibiting Folded P-Loop Conformation of MET Receptor Tyrosine Kinase.
Hassan et al. (2023)