› 7b5d

Electron Microscopy
3.3Å resolution

Structure of calcium-free mTMEM16A(ac)-I551A chloride channel at 3.3 A resolution

Released:
DOI: 10.2210/pdb7b5d/pdb
PDB entry 7b5d coloured by chain, front view.
PDB entry 7b5d coloured by chain, side view.
PDB entry 7b5d coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Gating the pore of the calcium-activated chloride channel TMEM16A.
Lam AKM, Rheinberger J, Paulino C, Dutzler R
OpenAccess logo Nat Commun 12 785 (2021)
PMID: 33542223
Related structures: EMD-12026

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183875 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Anoctamin-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 960 amino acids
Theoretical weight: 111.02 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8BHY3 (Residues: 1-960; Coverage: 100%)
Gene names: Ano1, Tmem16a
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.3Å
Relevant EMDB volumes: EMD-12026
Expression system: Homo sapiens

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Citations

5 review citations

Neutrophil dysfunction in the pathogenesis of cystic fibrosis.
Wang et al. (2022)
4 more

3 mentions without citation

Computational Investigation of Mechanisms for pH Modulation of Human Chloride Channels.
Elverson et al. (2023)
2 more