› 7bc8

X-ray diffraction
1.74Å resolution

Function and Biology Details

Reaction catalysed: 
[Wnt]-O-(9Z)-hexadec-9-enoyl-L-serine + H(2)O = [Wnt]-L-serine + (9Z)-hexadec-9-enoate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180133 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Palmitoleoyl-protein carboxylesterase NOTUM Chain: A
Molecule details ›
Chain: A
Length: 383 amino acids
Theoretical weight: 43.57 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6P988 (Residues: 81-451; Coverage: 78%)
Gene names: NOTUM, OK/SW-CL.30
Sequence domains: Pectinacetylesterase

Ligands and Environments

4 bound ligands:
Ligand SO4 6 x SO4
Ligand NAG 1 x NAG
Ligand EDO 2 x EDO
Ligand TAH 1 x TAH
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P212121
Unit cell:
a: 59.728Å b: 73.312Å c: 78.537Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.217 0.216 0.238
Expression system: Homo sapiens

Quick links

Citations

1 citations in other articles

Notum enhances gastric cancer stem-like cell properties through upregulation of Sox2 by PI3K/AKT signaling pathway.
Liu et al. (2023)

1 mention without citation

Structural Analysis and Development of Notum Fragment Screening Hits.
Zhao et al. (2022)