EC 5.2.1.8: Peptidylprolyl isomerase
Reaction catalysed:
Peptidylproline (omega=180) = peptidylproline (omega=0)
Systematic name:
Peptidylproline cis-trans-isomerase
Alternative Name(s):
- Cyclophilin
- PPIase
- Peptide bond isomerase
- Peptidyl-prolyl cis-trans isomerase
- Peptidylprolyl cis-trans isomerase
- Rotamase
GO terms
Biochemical function:
Biological process:
- negative regulation of stem cell proliferation
- positive regulation of protein localization
- negative regulation of protein localization to plasma membrane
- cAMP/PKA signal transduction
- stem cell proliferation
- establishment of skin barrier
- regulation of cell cycle
- positive regulation of protein export from nucleus
- negative regulation of innate immune response
- positive regulation of cell adhesion
- positive regulation of epidermal cell differentiation
- keratinocyte proliferation
- skin development
- regulation of protein localization
- keratinization
- positive regulation of cell growth
- keratinocyte differentiation
- regulation of cell-cell adhesion
- negative regulation of keratinocyte proliferation
- regulation of epidermal cell division
- intrinsic apoptotic signaling pathway in response to DNA damage
- protein localization
- signal transduction
- protein export from nucleus
- negative regulation of protein kinase activity
- keratinocyte development
- release of cytochrome c from mitochondria
- negative regulation of transcription by RNA polymerase II
Protein family (Pfam)
InterPro annotations