› 7be3

X-ray diffraction
1.25Å resolution

Human Galectin-3 in complex with LacdiNAc

Released:
DOI: 10.2210/pdb7be3/pdb
Model geometry
Fit model/data
PDB entry 7be3 coloured by chain, front view.
PDB entry 7be3 coloured by chain, side view.
PDB entry 7be3 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural Insights into the Molecular Recognition Mechanism of the Cancer and Pathogenic Epitope, LacdiNAc by Immune-Related Lectins.
Lima CDL, Coelho H, Gimeno A, Trovão F, Diniz A, Dias JS, Jiménez-Barbero J, Corzana F, Carvalho AL, Cabrita EJ, Marcelo F
Chemistry 27 7951-7958 (2021)
PMID: 33826192

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148215 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Galectin-3 Chain: A
Molecule details ›
Chain: A
Length: 138 amino acids
Theoretical weight: 15.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P17931 (Residues: 114-250; Coverage: 55%)
Gene names: LGALS3, MAC2
Sequence domains: Galactoside-binding lectin

Ligands and Environments

Carbohydrate polymer : NEW Components: NDG, NGA
Carbohydrate polymer
2 bound ligands:
Ligand GOL 1 x GOL
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ALBA BEAMLINE XALOC
Spacegroup: P212121
Unit cell:
a: 36.039Å b: 58.048Å c: 62.286Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.172 0.17 0.195
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

Biosynthesis and Biological Significances of LacdiNAc Group on N- and O-Glycans in Human Cancer Cells.
Hirano et al. (2022)
1 more