7bla

X-ray diffraction
1.09Å resolution

BAZ2A bromodomain in complex with TP-238 chemical probe

Released:
Source organism: Homo sapiens
Entry authors: Dalle Vedove A, Cazzanelli G, Caflisch A, Lolli G

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
PDBe Complex ID:
PDB-CPX-193785 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain adjacent to zinc finger domain protein 2A Chain: A
Molecule details ›
Chain: A
Length: 105 amino acids
Theoretical weight: 12.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UIF9 (Residues: 1796-1898; Coverage: 5%)
Gene names: BAZ2A, KIAA0314, TIP5
Sequence domains: Bromodomain

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ELETTRA BEAMLINE 11.2C
Spacegroup: P212121
Unit cell:
a: 35.645Å b: 50.942Å c: 67.733Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.14 0.14 0.161
Expression system: Escherichia coli