› 7bld

X-ray diffraction
2.35Å resolution

BAZ2A bromodomain in complex with compound UZH23

Released:
DOI: 10.2210/pdb7bld/pdb
PDB entry 7bld coloured by chain, front view.
PDB entry 7bld coloured by chain, side view.
PDB entry 7bld coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Dalle Vedove A, Cazzanelli G, Caflisch A, Lolli G

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-577460 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain adjacent to zinc finger domain protein 2A Chain: A
Molecule details ›
Chain: A
Length: 105 amino acids
Theoretical weight: 12.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9UIF9 (Residues: 1796-1898; Coverage: 5%)
Gene names: BAZ2A, KIAA0314, TIP5
Sequence domains: Bromodomain

Ligands and Environments

1 bound ligand:
Ligand U2K 2 x U2K
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ELETTRA BEAMLINE 5.2R
Spacegroup: P3121
Unit cell:
a: 94.872Å b: 94.872Å c: 32.539Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.192 0.19 0.23
Expression system: Escherichia coli BL21(DE3)

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