› 7bpv

X-ray diffraction
1.78Å resolution

r(GUGGGCCGAC)/d(GTCGGCCCAC) hybrid duplex structure

Released:
DOI: 10.2210/pdb7bpv/pdb
PDB entry 7bpv coloured by chain, front view.
PDB entry 7bpv coloured by chain, side view.
PDB entry 7bpv coloured by chain, top view.
Source organism: synthetic construct
Primary publication:
Targeting the ALS/FTD-associated A-DNA kink with anthracene-based metal complex causes DNA backbone straightening and groove contraction.
Jhan CR, Satange R, Wang SC, Zeng JY, Horng YC, Jin P, Neidle S, Hou MH
OpenAccess logo Nucleic Acids Res 49 9526-9538 (2021)
PMID: 33836081

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-121125 (preferred)
Entry contents:
1 distinct DNA molecule
1 distinct RNA molecule
Macromolecules (2 distinct):
DNA (5'-D(P*GP*TP*CP*GP*GP*CP*CP*CP*AP*C)-3') Chain: A
Molecule details ›
Chain: A
Length: 10 nucleotides
Theoretical weight: 3.01 KDa
Source organism: synthetic construct
Expression system: Not provided
RNA (5'-R(P*GP*UP*GP*GP*GP*CP*CP*GP*AP*C)-3') Chain: S
Molecule details ›
Chain: S
Length: 10 nucleotides
Theoretical weight: 3.23 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE TPS 05A
Spacegroup: P212121
Unit cell:
a: 28.348Å b: 46.647Å c: 47.859Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.22 0.218 0.238
Expression system: Not provided

Quick links

Citations

1 citations in other articles

Knowledge-based prediction of DNA hydration using hydrated dinucleotides as building blocks.
Biedermannová et al. (2022)

1 mention without citation

Targeting the ALS/FTD-associated A-DNA kink with anthracene-based metal complex causes DNA backbone straightening and groove contraction.
Jhan et al. (2021)