› 7bwa

Electron Microscopy
4.9Å resolution

Cryo-EM Structure for the Ectodomain of the Full-length Human Insulin Receptor in Complex with 2 Insulin

Released:
DOI: 10.2210/pdb7bwa/pdb
PDB entry 7bwa coloured by chain, front view.
PDB entry 7bwa coloured by chain, side view.
PDB entry 7bwa coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Yu D, Zhang X, Sun J, Li X, Wu Z, Han X, Fan C, Ma Y, Ouyang Q, Wang T
Related structures: EMD-30231

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134204 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Insulin receptor Chains: A, C
Molecule details ›
Chains: A, C
Length: 1355 amino acids
Theoretical weight: 154.11 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P06213 (Residues: 28-1382; Coverage: 100%)
Gene name: INSR
Sequence domains:
Insulin B chain Chains: D, E
Molecule details ›
Chains: D, E
Length: 74 amino acids
Theoretical weight: 8.38 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P01308 (Residues: 25-110; Coverage: 86%)
Gene name: INS
Sequence domains: Insulin/IGF/Relaxin family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.9Å
Relevant EMDB volumes: EMD-30231
Expression systems:
  • Homo sapiens
  • Saccharomyces cerevisiae

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