› 7byj

X-ray diffraction
2.49Å resolution

Crystal structure of the FERM domain of FRMPD4

Released:
DOI: 10.2210/pdb7byj/pdb
PDB entry 7byj coloured by chain, front view.
PDB entry 7byj coloured by chain, side view.
PDB entry 7byj coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the FERM domain of a neural scaffold protein FRMPD4 implicated in X-linked intellectual disability.
Wang M, Lin L, Shi Y, He L, Wang C, Zhu J
Biochem J 477 4623-4634 (2020)
PMID: 33216857

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172142 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
FERM and PDZ domain-containing protein 4 Chain: A
Molecule details ›
Chain: A
Length: 339 amino acids
Theoretical weight: 38.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q14CM0 (Residues: 193-527; Coverage: 25%)
Gene names: FRMPD4, KIAA0316, PDZD10, PDZK10
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P43212
Unit cell:
a: 49.149Å b: 49.149Å c: 350.225Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.228 0.224 0.266
Expression system: Escherichia coli BL21(DE3)

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Citations

1 review citation

The Complex Formed by Group I Metabotropic Glutamate Receptor (mGluR) and Homer1a Plays a Central Role in Metaplasticity and Homeostatic Synaptic Scaling.
Bockaert et al. (2021)