› 7byn

Electron Microscopy
3.3Å resolution

Cryo-EM structure of human KCNQ4 with linopirdine

Released:
DOI: 10.2210/pdb7byn/pdb
PDB entry 7byn coloured by chain, front view.
PDB entry 7byn coloured by chain, side view.
PDB entry 7byn coloured by chain, top view.
Source organisms:
Primary publication:
Structural Basis for the Modulation of Human KCNQ4 by Small-Molecule Drugs.
Li T, Wu K, Yue Z, Wang Y, Zhang F, Shen H
Mol Cell 81 25-37.e4 (2021)
PMID: 33238160
Related structures: EMD-30246

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-144006 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Green fluorescent protein; Potassium voltage-gated channel subfamily KQT member 4 Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 979 amino acids
Theoretical weight: 109.33 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
  • Canonical: P42212 (Residues: 2-238; Coverage: 100%)
  • Canonical: P56696 (Residues: 1-695; Coverage: 100%)
Gene names: GFP, KCNQ4
Sequence domains:
Calmodulin-3 Chains: B, D, F, H
Molecule details ›
Chains: B, D, F, H
Length: 149 amino acids
Theoretical weight: 16.85 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DP25 (Residues: 1-149; Coverage: 100%)
Gene names: CALM3, CALML2, CAM3, CAMC, CAMIII
Sequence domains: EF-hand domain pair

Ligands and Environments

3 bound ligands:
Ligand PT5 4 x PT5
Ligand K 3 x K
Ligand FCC 1 x FCC
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.3Å
Relevant EMDB volumes: EMD-30246
Expression system: Homo sapiens

Quick links

Citations

5 review citations

Activation of KCNQ4 as a Therapeutic Strategy to Treat Hearing Loss.
Rim et al. (2021)
4 more

2 mentions without citation

Pose Classification Using Three-Dimensional Atomic Structure-Based Neural Networks Applied to Ion Channel-Ligand Docking.
Shim et al. (2022)
1 more