7c77

Electron Microscopy
3.3Å resolution

Cryo-EM structure of mouse TLR3 in complex with UNC93B1

Released:
Source organism: Mus musculus
Primary publication:
Cryo-EM structures of Toll-like receptors in complex with UNC93B1.
Nat Struct Mol Biol 28 173-180 (2021)
PMID: 33432245
Related structures: EMD-30294

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-186558 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (4 distinct):
Toll-like receptor 3 Chain: A
Molecule details ›
Chain: A
Length: 905 amino acids
Theoretical weight: 103.79 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q99MB1 (Residues: 1-905; Coverage: 100%)
Gene name: Tlr3
Sequence domains:
Protein unc-93 homolog B1 Chain: B
Molecule details ›
Chain: B
Length: 598 amino acids
Theoretical weight: 67.04 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8VCW4 (Residues: 1-598; Coverage: 100%)
Gene names: Unc93b, Unc93b1

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer : NEW Components: NAG
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.3Å
Relevant EMDB volumes: EMD-30294
Expression system: Homo sapiens