› 7ce4

X-ray diffraction
1.5Å resolution

Function and Biology Details

Reaction catalysed: 
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-574338 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Poly [ADP-ribose] polymerase tankyrase-2 Chain: A
Molecule details ›
Chain: A
Length: 191 amino acids
Theoretical weight: 21.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H2K2 (Residues: 946-1113; Coverage: 14%)
Gene names: PARP5B, TANK2, TNKL, TNKS2
Sequence domains: Poly(ADP-ribose) polymerase catalytic domain
Poly [ADP-ribose] polymerase tankyrase-2 Chain: B
Molecule details ›
Chain: B
Length: 49 amino acids
Theoretical weight: 5.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H2K2 (Residues: 1114-1162; Coverage: 4%)
Gene names: PARP5B, TANK2, TNKL, TNKS2

Ligands and Environments

4 bound ligands:
Ligand ZN 1 x ZN
Ligand SO4 2 x SO4
Ligand KK6 1 x KK6
Ligand PG4 1 x PG4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-17A
Spacegroup: P41212
Unit cell:
a: 66.534Å b: 66.534Å c: 116.815Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.174 0.173 0.203
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Targeting the Wnt/β-Catenin Signaling Pathway as a Potential Therapeutic Strategy in Renal Tubulointerstitial Fibrosis.
Li et al. (2021)
3 other articles

2 mentions without citation

The dual pocket binding novel tankyrase inhibitor K-476 enhances the efficacy of immune checkpoint inhibitor by attracting CD8+ T cells to tumors.
Kinosada et al. (2021)
1 more