7cj0 › Citations

DNAJC9 integrates heat shock molecular chaperones into the histone chaperone network.
<div class='caption-title'>Identification of DNAJC9 as a dual histone chaperone and heat shock co-chaperone</div>
<div class='caption-title'>Structure of DNAJC9 and MCM2 bound simultaneously to an H3.3-H4 dimer</div>
Hammond CM, Bao H, Hendriks IA, Carraro M, García-Nieto A, Liu Y, Reverón-Gómez N, Spanos C, Chen L, Rappsilber J, Nielsen ML, Patel DJ, Huang H, Groth A
OpenAccess logo Mol Cell 81 2533-2548.e9 (2021)
Cited: 18 times
EuropePMC logo PMID: 33857403

Abstract

From biosynthesis to assembly into nucleosomes, histones are handed through a cascade of histone chaperones, which shield histones from non-specific interactions. Whether mechanisms exist to safeguard the histone fold during histone chaperone handover events or to release trapped intermediates is unclear. Using structure-guided and functional proteomics, we identify and characterize a histone chaperone function of DNAJC9, a heat shock co-chaperone that promotes HSP70-mediated catalysis. We elucidate the structure of DNAJC9, in a histone H3-H4 co-chaperone complex with MCM2, revealing how this dual histone and heat shock co-chaperone binds histone substrates. We show that DNAJC9 recruits HSP70-type enzymes via its J domain to fold histone H3-H4 substrates: upstream in the histone supply chain, during replication- and transcription-coupled nucleosome assembly, and to clean up spurious interactions. With its dual functionality, DNAJC9 integrates ATP-resourced protein folding into the histone supply pathway to resolve aberrant intermediates throughout the dynamic lives of histones.

Articles - 7cj0 mentioned but not cited (1)

  1. DNAJC9 integrates heat shock molecular chaperones into the histone chaperone network. Hammond CM, Bao H, Hendriks IA, Carraro M, García-Nieto A, Liu Y, Reverón-Gómez N, Spanos C, Chen L, Rappsilber J, Nielsen ML, Patel DJ, Huang H, Groth A. Mol Cell 81 2533-2548.e9 (2021)


Reviews citing this publication (3)

  1. Regulation of p53 and Cancer Signaling by Heat Shock Protein 40/J-Domain Protein Family Members. Kaida A, Iwakuma T. Int J Mol Sci 22 13527 (2021)
  2. The Astonishing Large Family of HSP40/DnaJ Proteins Existing in Leishmania. Solana JC, Bernardo L, Moreno J, Aguado B, Requena JM. Genes (Basel) 13 742 (2022)
  3. Interaction of client-the scaffold on which FeS clusters are build-with J-domain protein Hsc20 and its evolving Hsp70 partners. Marszalek J, Craig EA. Front Mol Biosci 9 1034453 (2022)

Articles citing this publication (14)

  1. NASP maintains histone H3-H4 homeostasis through two distinct H3 binding modes. Bao H, Carraro M, Flury V, Liu Y, Luo M, Chen L, Groth A, Huang H. Nucleic Acids Res 50 5349-5368 (2022)
  2. ATAD2 controls chromatin-bound HIRA turnover. Wang T, Perazza D, Boussouar F, Cattaneo M, Bougdour A, Chuffart F, Barral S, Vargas A, Liakopoulou A, Puthier D, Bargier L, Morozumi Y, Jamshidikia M, Garcia-Saez I, Petosa C, Rousseaux S, Verdel A, Khochbin S. Life Sci Alliance 4 e202101151 (2021)
  3. Stable inheritance of H3.3-containing nucleosomes during mitotic cell divisions. Xu X, Duan S, Hua X, Li Z, He R, Zhang Z. Nat Commun 13 2514 (2022)
  4. A specific role for importin-5 and NASP in the import and nuclear hand-off of monomeric H3. Pardal AJ, Bowman AJ. Elife 11 e81755 (2022)
  5. Chaperone mediated autophagy contributes to the newly synthesized histones H3 and H4 quality control. Hormazabal J, Saavedra F, Espinoza-Arratia C, Martinez NW, Cruces T, Alfaro IE, Loyola A. Nucleic Acids Res 50 1875-1887 (2022)
  6. DAXX adds a de novo H3.3K9me3 deposition pathway to the histone chaperone network. Carraro M, Hendriks IA, Hammond CM, Solis-Mezarino V, Völker-Albert M, Elsborg JD, Weisser MB, Spanos C, Montoya G, Rappsilber J, Imhof A, Nielsen ML, Groth A. Mol Cell 83 1075-1092.e9 (2023)
  7. Human papillomavirus infection can alter the level of tumour stemness and T cell infiltration in patients with head and neck squamous cell carcinoma. Meng L, Lu H, Li Y, Zhao J, He S, Wang Z, Shen J, Huang H, Xiao J, Sooranna SR, Song J. Front Immunol 13 1013542 (2022)
  8. Proteotranscriptomics of ocular adnexal B-cell lymphoma reveals an oncogenic role of alternative splicing and identifies a diagnostic marker. Shi J, Zhu T, Lin H, Liu Z, Zhou M, Yu Z, Zhou X, Song X, Wang Y, Jia R, Fan X, Zhou Y. J Exp Clin Cancer Res 41 234 (2022)
  9. CAF-1 deposits newly synthesized histones during DNA replication using distinct mechanisms on the leading and lagging strands. Rouillon C, Eckhardt BV, Kollenstart L, Gruss F, Verkennis AEE, Rondeel I, Krijger PHL, Ricci G, Biran A, van Laar T, Delvaux de Fenffe CM, Luppens G, Albanese P, Sato K, Scheltema RA, de Laat W, Knipscheer P, Dekker NH, Groth A, Mattiroli F. Nucleic Acids Res 51 3770-3792 (2023)
  10. Identifying the genes impacted by cell proliferation in proteomics and transcriptomics studies. Locard-Paulet M, Palasca O, Jensen LJ. PLoS Comput Biol 18 e1010604 (2022)
  11. A J Domain Protein Functions as a Histone Chaperone to Maintain Genome Integrity and the Response to DNA Damage in a Human Fungal Pathogen. Horianopoulos LC, Lee CWJ, Schmitt K, Valerius O, Hu G, Caza M, Braus GH, Kronstad JW. mBio 12 e0327321 (2021)
  12. H4S47 O-GlcNAcylation regulates the activation of mammalian replication origins. Zou Y, Pei J, Long H, Lan L, Dong K, Wang T, Li M, Zhao Z, Zhu L, Zhang G, Jin X, Wang Y, Wen Z, Wei M, Feng Y. Nat Struct Mol Biol 30 800-811 (2023)
  13. Histone chaperones: A multinodal highway network inside the cell. Li Z, Zhang Z. Mol Cell 83 1024-1026 (2023)
  14. Obatoclax Rescues FUS-ALS Phenotypes in iPSC-Derived Neurons by Inducing Autophagy. Castillo Bautista CM, Eismann K, Gentzel M, Pelucchi S, Mertens J, Walters HE, Yun MH, Sterneckert J. Cells 12 2247 (2023)


Quick links