› 7cje

X-ray diffraction
1.95Å resolution

Structural and kinetic characterization of Porphyromonas gingivalis glutaminyl cyclase

Released:
DOI: 10.2210/pdb7cje/pdb
PDB entry 7cje coloured by chain, front view.
PDB entry 7cje coloured by chain, side view.
PDB entry 7cje coloured by chain, top view.
Source organism: Porphyromonas gingivalis W83
Primary publication:
Structural and kinetic characterization of Porphyromonas gingivalis glutaminyl cyclase.
Lamers S, Feng Q, Cheng Y, Yu S, Sun B, Lukman M, Jiang J, Ruiz-Carrillo D
Biol Chem 402 759-768 (2021)
PMID: 33823093

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-565905 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidase M28 domain-containing protein Chains: A, C
Molecule details ›
Chains: A, C
Length: 333 amino acids
Theoretical weight: 36.57 KDa
Source organism: Porphyromonas gingivalis W83
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q7MT37 (Residues: 1-1, 22-333; Coverage: 94%)
Gene name: PG_2157
Sequence domains: Peptidase family M28

Ligands and Environments

3 bound ligands:
Ligand ZN 2 x ZN
Ligand MG 2 x MG
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL18U1
Spacegroup: P3121
Unit cell:
a: 90.8Å b: 90.8Å c: 164.5Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.183 0.183 0.209
Expression system: Escherichia coli BL21(DE3)

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Citations

1 review citation

Development and evolution of human glutaminyl cyclase inhibitors (QCIs): an alternative promising approach for disease-modifying treatment of Alzheimer's disease.
Chen et al. (2023)
1 other article