7clh

X-ray diffraction
2.9Å resolution

Crystal structure of TTK kinase domain in complex with compound 19

Released:
Model geometry
Fit model/data

Function and Biology Details

Reaction catalysed:
ATP + L-seryl/L-threonyl/L-tyrosyl-[protein] = ADP + O-phospho-L-seryl/O-phospho-L-threonyl/O-phospho-L-tyrosyl-[protein]
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
PDBe Complex ID:
PDB-CPX-152667 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dual specificity protein kinase TTK Chain: A
Molecule details ›
Chain: A
Length: 283 amino acids
Theoretical weight: 33.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: P33981 (Residues: 515-795; Coverage: 33%)
Gene names: MPS1, MPS1L1, TTK
Sequence domains: Protein kinase domain

Ligands and Environments

1 bound ligand:
2 modified residues:

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: PAL/PLS BEAMLINE 5C (4A)
Spacegroup: I222
Unit cell:
a: 70.801Å b: 109.907Å c: 113.218Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.204 0.272
Expression system: Escherichia coli K-12