7cm4

X-ray diffraction
2.71Å resolution

Crystal Structure of COVID-19 virus spike receptor-binding domain complexed with a neutralizing antibody CT-P59

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-209722 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Spike protein S1 Chain: A
Molecule details ›
Chain: A
Length: 226 amino acids
Theoretical weight: 25.63 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P0DTC2 (Residues: 319-536; Coverage: 17%)
Gene names: 2, S
Sequence domains: Betacoronavirus spike glycoprotein S1, receptor binding
IgG heavy chain Chain: H
Molecule details ›
Chain: H
Length: 458 amino acids
Theoretical weight: 50.55 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
IgG light chain Chain: L
Molecule details ›
Chain: L
Length: 216 amino acids
Theoretical weight: 22.66 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, MAN, FUC
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 5C (4A)
Spacegroup: I222
Unit cell:
a: 65.55Å b: 167.6Å c: 169.05Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.219 0.217 0.242
Expression systems:
  • Spodoptera frugiperda
  • Cricetulus griseus