› 7coe

X-ray diffraction
2.05Å resolution

Crystal structure of Receptor binding domain of MERS-CoV and KNIH90-F1 Fab complex

Released:
DOI: 10.2210/pdb7coe/pdb
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PDB entry 7coe coloured by chain, front view.
PDB entry 7coe coloured by chain, side view.
PDB entry 7coe coloured by chain, top view.
Source organisms:
Primary publication:
The structure of a novel antibody against the spike protein inhibits Middle East respiratory syndrome coronavirus infections.
Jang TH, Park WJ, Lee H, Woo HM, Lee SY, Kim KC, Kim SS, Hong E, Song J, Lee JY
OpenAccess logo Sci Rep 12 1260 (2022)
PMID: 35075213

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-224841 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Heavy chain Chains: B, H
Molecule details ›
Chains: B, H
Length: 237 amino acids
Theoretical weight: 25.22 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Light chain Chains: C, L
Molecule details ›
Chains: C, L
Length: 215 amino acids
Theoretical weight: 23.26 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Spike protein S1 Chains: A, D

Ligands and Environments

2 bound ligands:
Ligand EDO 29 x EDO
Ligand NAG 4 x NAG
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: PAL/PLS BEAMLINE 5C (4A)
Spacegroup: P21
Unit cell:
a: 71.59Å b: 146.819Å c: 81.622Å
α: 90° β: 96.73° γ: 90°
R-values:
R R work R free
0.176 0.176 0.223
Expression systems:
  • Homo sapiens
  • Spodoptera frugiperda

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Citations

1 citations in other articles

The emergence of SARS-CoV-2 lineages and associated saliva antibody responses among asymptomatic individuals in a large university community.
Merling et al. (2023)

1 mention without citation

The structure of a novel antibody against the spike protein inhibits Middle East respiratory syndrome coronavirus infections.
Jang et al. (2022)

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