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Crystal structure of isocitrate lyase in complex with succinate and itaconate

Source organism: Mycobacterium tuberculosis H37Rv
Biochemical function: metal ion binding
Biological process: cellular response to hypoxia
Cellular component: plasma membrane

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EC 4.1.3.1: Isocitrate lyase

Reaction catalysed:
Isocitrate = succinate + glyoxylate
Systematic name:
Isocitrate glyoxylate-lyase (succinate-forming)
Alternative Name(s):
  • ICL
  • Isocitrase
  • Isocitratase
  • Isocitrate glyoxylate-lyase
  • Isocitritase
  • Threo-D(S)-isocitrate glyoxylate-lyase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00463
Domain description: Isocitrate lyase family
Occurring in:
  1. Isocitrate lyase
The deposited structure of PDB entry 7cp1 contains 4 copies of Pfam domain PF00463 (Isocitrate lyase family) in Isocitrate lyase. Showing 2 copies in chain B.

InterPro InterPro annotations
IPR006254
Domain description: Isocitrate lyase
Occurring in:
  1. Isocitrate lyase
IPR018523
Domain description: Isocitrate lyase/phosphorylmutase, conserved site
Occurring in:
  1. Isocitrate lyase
IPR015813
Domain description: Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily
Occurring in:
  1. Isocitrate lyase
IPR040442
Domain description: Pyruvate kinase-like domain superfamily
Occurring in:
  1. Isocitrate lyase

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