› 7csr

X-ray diffraction
3Å resolution

Structure of Ephexin4 R676L

Released:
DOI: 10.2210/pdb7csr/pdb
PDB entry 7csr coloured by chain, front view.
PDB entry 7csr coloured by chain, side view.
PDB entry 7csr coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Double inhibition and activation mechanisms of Ephexin family RhoGEFs.
Zhang M, Lin L, Wang C, Zhu J
Proc Natl Acad Sci U S A 118 (2021)
PMID: 33597305

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-559181 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Rho guanine nucleotide exchange factor 16 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 459 amino acids
Theoretical weight: 52.52 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q3U5C8 (Residues: 261-713; Coverage: 64%)
Gene name: Arhgef16
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: C2221
Unit cell:
a: 147.075Å b: 244.729Å c: 141.744Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.214 0.212 0.255
Expression system: Escherichia coli BL21(DE3)

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Citations

1 review citation

A Systematic Compilation of Human SH3 Domains: A Versatile Superfamily in Cellular Signaling.
Mehrabipour et al. (2023)
3 other articles