7cvz

Electron Microscopy
4.7Å resolution

Cryo-EM structure of Chikungunya virus in complex with Fab fragments of mAb CHK-263

Released:
Source organisms:
Related structures: EMD-30477

Function and Biology Details

Reaction catalysed:
Autocatalytic release of the core protein from the N-terminus of the togavirus structural polyprotein by hydrolysis of a -Trp-|-Ser- bond.
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero 960-mer (preferred)
PDBe Complex ID:
PDB-CPX-212615 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Spike glycoprotein E1 Chains: A, D, G, J
Molecule details ›
Chains: A, D, G, J
Length: 439 amino acids
Theoretical weight: 47.5 KDa
Source organism: Chikungunya virus
UniProt:
  • Canonical: Q8JUX5 (Residues: 810-1248; Coverage: 35%)
Sequence domains: Alphavirus E1 glycoprotein
Spike glycoprotein E2 Chains: B, E, H, K
Molecule details ›
Chains: B, E, H, K
Length: 419 amino acids
Theoretical weight: 46.9 KDa
Source organism: Chikungunya virus
UniProt:
  • Canonical: Q8JUX5 (Residues: 330-748; Coverage: 34%)
Sequence domains: Alphavirus E2 glycoprotein
Capsid protein Chains: C, F, I, L
Fab heavy chain Chains: O, Q
Fab light chain Chains: P, R

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.7Å
Relevant EMDB volumes: EMD-30477