› 7cwm

Electron Microscopy
3.6Å resolution

Complex of SARS-CoV-2 spike protein and Fab P17 with one RBD in open state and two RBD in closed state

Released:
DOI: 10.2210/pdb7cwm/pdb
PDB entry 7cwm coloured by chain, front view.
PDB entry 7cwm coloured by chain, side view.
PDB entry 7cwm coloured by chain, top view.
Source organisms:
Primary publication:
Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection.
Yao H, Sun Y, Deng YQ, Wang N, Tan Y, Zhang NN, Li XF, Kong C, Xu YP, Chen Q, Cao TS, Zhao H, Yan X, Cao L, Lv Z, Zhu D, Feng R, Wu N, Zhang W, Hu Y, Chen K, Zhang RR, Lv Q, Sun S, Zhou Y, Yan R, Yang G, Sun X, Liu C, Lu X, Cheng L, Qiu H, Huang XY, Weng T, Shi D, Jiang W, Shao J, Wang L, Zhang J, Jiang T, Lang G, Qin CF, Li L, Wang X
OpenAccess logo Cell Res 31 25-36 (2021)
PMID: 33262452
Related structures: EMD-30483

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero nonamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-210144 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Spike glycoprotein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 1273 amino acids
Theoretical weight: 141.3 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 1-1273; Coverage: 100%)
Gene names: 2, S
Sequence domains:
P17 heavy chain Chains: G, H, I
Molecule details ›
Chains: G, H, I
Length: 120 amino acids
Theoretical weight: 13.17 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
P17 light chain Chains: J, K, L
Molecule details ›
Chains: J, K, L
Length: 108 amino acids
Theoretical weight: 11.62 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 16 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.6Å
Relevant EMDB volumes: EMD-30483
Expression system: Homo sapiens

Quick links

Citations

15 review citations

Structural biology of SARS-CoV-2 and implications for therapeutic development.
Yang et al. (2021)
14 more

7 mentions without citation

Native, engineered and de novo designed ligands targeting the SARS-CoV-2 spike protein.
Costa et al. (2022)
6 more