› 7czd

X-ray diffraction
1.64Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-212805 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
anti-PD-L1 VHH Chains: A, C
Molecule details ›
Chains: A, C
Length: 116 amino acids
Theoretical weight: 12.66 KDa
Source organism: Lama glama
Expression system: Homo sapiens
Programmed cell death 1 ligand 1 Chains: B, D
Molecule details ›
Chains: B, D
Length: 117 amino acids
Theoretical weight: 13.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NZQ7 (Residues: 19-134; Coverage: 43%)
Gene names: B7H1, CD274, PDCD1L1, PDCD1LG1, PDL1
Sequence domains: Immunoglobulin V-set domain

Ligands and Environments

2 bound ligands:
Ligand EDO 6 x EDO
Ligand PEG 1 x PEG
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P21
Unit cell:
a: 34.62Å b: 97.99Å c: 67.52Å
α: 90° β: 90.02° γ: 90°
R-values:
R R work R free
0.151 0.15 0.184
Expression systems:
  • Homo sapiens
  • Escherichia coli

Quick links

Citations

11 review citations

Combination strategies with PD-1/PD-L1 blockade: current advances and future directions.
Yi et al. (2022)
10 more

1 mention without citation

Generation of a safe and efficacious llama single-domain antibody fragment (vHH) targeting the membrane-proximal region of 4-1BB for engineering therapeutic bispecific antibodies for cancer.
Zhai et al. (2021)

PDB-REDO

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