7d4g

Electron Microscopy
3.9Å resolution

A proof of concept for neutralizing antibody-guided vaccine design against SARS-CoV-2

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-279640 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Spike protein S1 Chain: B
Molecule details ›
Chain: B
Length: 278 amino acids
Theoretical weight: 31.66 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 13-290; Coverage: 22%)
Gene names: 2, S
Sequence domains: Betacoronavirus-like spike glycoprotein S1, N-terminal
Light chain of FC05 Fab Chain: G
Molecule details ›
Chain: G
Length: 110 amino acids
Theoretical weight: 11.35 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Heavy chain of FC05 Fab Chain: N
Molecule details ›
Chain: N
Length: 122 amino acids
Theoretical weight: 13.46 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.9Å
Relevant EMDB volumes: EMD-30573
Expression system: Homo sapiens