› 7d7e

Electron Microscopy
3.4Å resolution

Structure of PKD1L3-CTD/PKD2L1 in apo state

Released:
DOI: 10.2210/pdb7d7e/pdb
PDB entry 7d7e coloured by chain, front view.
PDB entry 7d7e coloured by chain, side view.
PDB entry 7d7e coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural basis for Ca2+ activation of the heteromeric PKD1L3/PKD2L1 channel.
Su Q, Chen M, Wang Y, Li B, Jing D, Zhan X, Yu Y, Shi Y
OpenAccess logo Nat Commun 12 4871 (2021)
PMID: 34381056
Related structures: EMD-30606

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-106803 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Polycystin-2-like protein 1 Chains: B, C, D
Molecule details ›
Chains: B, C, D
Length: 604 amino acids
Theoretical weight: 69.23 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: A2A259 (Residues: 64-629; Coverage: 75%)
Gene names: Pkd2l1, Trpp3
Sequence domains:
Polycystin-1-like protein 3 Chain: A
Molecule details ›
Chain: A
Length: 551 amino acids
Theoretical weight: 62.54 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q2EG98 (Residues: 1642-2160; Coverage: 24%)
Gene names: 71B10, Pkd1l3
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand NAG 10 x NAG
Ligand CA 3 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.4Å
Relevant EMDB volumes: EMD-30606
Expression system: Homo sapiens

Quick links

Citations

2 review citations

Cerebrospinal fluid-contacting neurons: multimodal cells with diverse roles in the CNS.
Wyart et al. (2023)
1 more

1 mention without citation

Polycystin Channel Complexes.
Esarte Palomero et al. (2023)