7d8p

X-ray diffraction
2Å resolution

CRTC1 pSer151 peptide in complex with 14-3-3 zeta

Released:
Model geometry
Fit model/data
Source organism: Homo sapiens
Primary publication:
Structural Insights into the Interaction Between CRTCs and 14-3-3.
J Mol Biol 433 166874 (2021)
PMID: 33556406

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-158981 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
14-3-3 protein zeta/delta Chains: A, B
Molecule details ›
Chains: A, B
Length: 265 amino acids
Theoretical weight: 29.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P63104 (Residues: 1-245; Coverage: 100%)
Gene name: YWHAZ
Sequence domains: 14-3-3 protein
CREB-regulated transcription coactivator 1 Chains: C, D
Molecule details ›
Chains: C, D
Length: 11 amino acids
Theoretical weight: 1.43 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q6UUV9 (Residues: 146-156; Coverage: 2%)
Gene names: CRTC1, KIAA0616, MECT1, TORC1, WAMTP1

Ligands and Environments

1 bound ligand:
1 modified residue:

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: P212121
Unit cell:
a: 71.466Å b: 83.533Å c: 112.077Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.202 0.201 0.229
Expression systems:
  • Escherichia coli
  • Not provided