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Crystal Structure of Recombinant Human Acetylcholinesterase in Complex with Compound 2

X-ray diffraction
2.45Å resolution
PDB entry 7d9o coloured by chain, front view.
PDB entry 7d9o coloured by chain, side view.
PDB entry 7d9o coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Acetylcholinesterase
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Multimeric state: homo dimer
Accessible surface area: 36927.4 Å2
Buried surface area: 3635.45 Å2
Dissociation area: 980.72 Å2
Dissociation energy (ΔGdiss): 1.07 kcal/mol
Dissociation entropy (TΔSdiss): 14.47 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-149584

Macromolecules

Acetylcholinesterase
Chains: A, B
Length: 553 amino acids
Theoretical weight: 60.83 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P22303 (Residues: 32-574; Coverage: 93%)
Gene name: ACHE
Pfam: Carboxylesterase family
InterPro:
Acetylcholinesterase in PDB entry 7d9o, assembly 1, front view.
Acetylcholinesterase in PDB entry 7d9o, assembly 1, side view.
Acetylcholinesterase in PDB entry 7d9o, assembly 1, top view.
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