› 7df1

X-ray diffraction
2.81Å resolution

Crystal structure of human CD98 heavy chain extracellular domain in complex with S1-F4 scFv

Released:
DOI: 10.2210/pdb7df1/pdb
Model geometry
Fit model/data
PDB entry 7df1 coloured by chain, front view.
PDB entry 7df1 coloured by chain, side view.
PDB entry 7df1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
An anti-CD98 antibody displaying pH-dependent Fc-mediated tumour-specific activity against multiple cancers in CD98-humanized mice.
Tian X, Liu X, Ding J, Wang F, Wang K, Liu J, Wei Z, Hao X, Li Y, Wei X, Zhang H, Sui J
Nat Biomed Eng (2022)
PMID: 36424464

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-207477 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Amino acid transporter heavy chain SLC3A2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 420 amino acids
Theoretical weight: 46.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P08195 (Residues: 212-630; Coverage: 67%)
Gene names: MDU1, SLC3A2
Sequence domains: Alpha amylase, catalytic domain
S1-F4 VH Chains: E, F, G, H
Molecule details ›
Chains: E, F, G, H
Length: 140 amino acids
Theoretical weight: 14.74 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Ig-like domain-containing protein Chains: I, J, K, L

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P212121
Unit cell:
a: 125.802Å b: 165.212Å c: 176.191Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.218 0.217 0.249
Expression systems:
  • Escherichia coli
  • Homo sapiens

Quick links

Citations

1 review citation

CD98 heavy chain as a prognostic biomarker and target for cancer treatment.
Xia et al. (2023)
3 other articles

PDB-REDO

The sliders below show the change in model quality between original PDB entry and the PDB-REDO entry

Model Geometry
 
 
Data not available
DNA/RNA Geometry
 
 
Data not available
Fit model/data
 
 
Data not available
PDB-REDO