7dfl

Electron Microscopy
3.3Å resolution

Cryo-EM structure of histamine H1 receptor Gq complex

Released:
Source organism: Homo sapiens
Primary publication:
Cryo-EM structure of the human histamine H1 receptor/Gq complex.
OpenAccess logo Nat Commun 12 2086 (2021)
PMID: 33828102
Related structures: EMD-30665

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-211095 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Histamine H1 receptor Chain: R
Molecule details ›
Chain: R
Length: 487 amino acids
Theoretical weight: 55.86 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Chain: B
Molecule details ›
Chain: B
Length: 339 amino acids
Theoretical weight: 37.29 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Chain: G
Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding protein G(q) subunit alpha Chain: A
scFv16 Chain: C

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.3Å
Relevant EMDB volumes: EMD-30665
Expression system: Spodoptera frugiperda