› 7dfw

Electron Microscopy
2.69Å resolution

Cryo_EM structure of delta N-NPC1L1-CLR

Released:
DOI: 10.2210/pdb7dfw/pdb
PDB entry 7dfw coloured by chain, front view.
PDB entry 7dfw coloured by chain, side view.
PDB entry 7dfw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into the mechanism of human NPC1L1-mediated cholesterol uptake.
Hu M, Yang F, Huang Y, You X, Liu D, Sun S, Sui SF
OpenAccess logo Sci Adv 7 (2021)
PMID: 34272236
Related structures: EMD-30666

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193738 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (4 distinct):
NPC1-like intracellular cholesterol transporter 1 Chain: A
Molecule details ›
Chain: A
Length: 1288 amino acids
Theoretical weight: 141.21 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9UHC9 (Residues: 1-1315; Coverage: 95%)
  • Best match: Q9UHC9-2 (Residues: 1-1288)
Gene name: NPC1L1
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
4 bound ligands:
Ligand NAG 7 x NAG
Ligand P5S 1 x P5S
Ligand LMT 1 x LMT
Ligand CLR 6 x CLR
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.69Å
Relevant EMDB volumes: EMD-30666
Expression system: Homo sapiens

Quick links

Citations

7 review citations

Regulation of cholesterol homeostasis in health and diseases: from mechanisms to targeted therapeutics.
Duan et al. (2022)
6 more