› 7dg4

X-ray diffraction
2.58Å resolution

The co-crystal structure of DYRK2 with a small molecule inhibitor 6

Released:
DOI: 10.2210/pdb7dg4/pdb
PDB entry 7dg4 coloured by chain, front view.
PDB entry 7dg4 coloured by chain, side view.
PDB entry 7dg4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry.
Wei T, Wang J, Liang R, Chen W, Chen Y, Ma M, He A, Du Y, Zhou W, Zhang Z, Zeng X, Wang C, Lu J, Guo X, Chen XW, Wang Y, Tian R, Xiao J, Lei X
OpenAccess logo Elife 11 (2022)
PMID: 35439114

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187711 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dual specificity tyrosine-phosphorylation-regulated kinase 2 Chain: A
Molecule details ›
Chain: A
Length: 324 amino acids
Theoretical weight: 37.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli K-12

Ligands and Environments

1 bound ligand:
Ligand H5R 1 x H5R
2 modified residues:
Ligand PTR 1 x PTR
Ligand SEP 1 x SEP

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: C2221
Unit cell:
a: 64.58Å b: 128.88Å c: 132.48Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.206 0.201 0.25
Expression system: Escherichia coli K-12

Quick links

Citations

2 review citations

STIM and Orai Mediated Regulation of Calcium Signaling in Age-Related Diseases.
Collins et al. (2022)
1 more