› 7dho

X-ray diffraction
3.29Å resolution

The co-crystal structure of DYRK2 with a small molecule inhibitor 14

Released:
DOI: 10.2210/pdb7dho/pdb
PDB entry 7dho coloured by chain, front view.
PDB entry 7dho coloured by chain, side view.
PDB entry 7dho coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry.
Wei T, Wang J, Liang R, Chen W, Chen Y, Ma M, He A, Du Y, Zhou W, Zhang Z, Zeng X, Wang C, Lu J, Guo X, Chen XW, Wang Y, Tian R, Xiao J, Lei X
OpenAccess logo Elife 11 (2022)
PMID: 35439114

Function and Biology Details

Reaction catalysed: 
ATP + L-seryl/L-threonyl/L-tyrosyl-[protein] = ADP + O-phospho-L-seryl/O-phospho-L-threonyl/O-phospho-L-tyrosyl-[protein]
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187711 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dual specificity tyrosine-phosphorylation-regulated kinase 2 Chain: A
Molecule details ›
Chain: A
Length: 324 amino acids
Theoretical weight: 37.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: Q92630 (Residues: 215-538; Coverage: 54%)
Gene name: DYRK2
Sequence domains: Protein kinase domain

Ligands and Environments

1 bound ligand:
Ligand H7U 1 x H7U
2 modified residues:
Ligand PTR 1 x PTR
Ligand SEP 1 x SEP

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: C2221
Unit cell:
a: 64.61Å b: 128.87Å c: 133.74Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.184 0.259
Expression system: Escherichia coli K-12

Quick links

Citations

1 review citation

STIM and Orai Mediated Regulation of Calcium Signaling in Age-Related Diseases.
Collins et al. (2022)
2 other articles