› 7dhx

X-ray diffraction
2.3Å resolution

Crystal structure of SARS-CoV-2 RBD binding to pangolin ACE2

Released:
DOI: 10.2210/pdb7dhx/pdb
PDB entry 7dhx coloured by chain, front view.
PDB entry 7dhx coloured by chain, side view.
PDB entry 7dhx coloured by chain, top view.
Source organisms:
Primary publication:
Molecular basis of pangolin ACE2 engaged by COVID-19 virus
Wu L, Gao G, Yan J, Wang Q, Niu S, Chen Q, Qi J, Zhang Y, Jiaqi S, Shi Y
Chin. Sci. Bull. 66 73-84 (2021)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-144176 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
pangolin ACE2 Chain: A
Molecule details ›
Chain: A
Length: 601 amino acids
Theoretical weight: 69.94 KDa
Source organism: Manis javanica
Expression system: Spodoptera frugiperda
Spike protein S1 Chain: B
Molecule details ›
Chain: B
Length: 209 amino acids
Theoretical weight: 23.51 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P0DTC2 (Residues: 319-527; Coverage: 17%)
Gene names: 2, S
Sequence domains: Betacoronavirus spike glycoprotein S1, receptor binding

Ligands and Environments

2 bound ligands:
Ligand NAG 2 x NAG
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: C2
Unit cell:
a: 139.996Å b: 97.564Å c: 90.982Å
α: 90° β: 129.154° γ: 90°
R-values:
R R work R free
0.196 0.194 0.235
Expression system: Spodoptera frugiperda

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