› 7dmd

Solution NMR

Solution structure of human Aha1 N-terminal domain

Released:
DOI: 10.2210/pdb7dmd/pdb
PDB entry 7dmd coloured by chain, ensemble of 20 models, front view.
PDB entry 7dmd coloured by chain, ensemble of 20 models, side view.
PDB entry 7dmd coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Aha1 Exhibits Distinctive Dynamics Behavior and Chaperone-Like Activity.
Hu H, Wang Q, Du J, Liu Z, Ding Y, Xue H, Zhou C, Feng L, Zhang N
OpenAccess logo Molecules 26 (2021)
PMID: 33808352

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131931 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Activator of 90 kDa heat shock protein ATPase homolog 1 Chain: A
Molecule details ›
Chain: A
Length: 135 amino acids
Theoretical weight: 15.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O95433 (Residues: 28-162; Coverage: 40%)
Gene names: AHSA1, C14orf3, HSPC322
Sequence domains: Activator of Hsp90 ATPase, N-terminal

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 75%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

4 citation in other articles

Pharmacological characterization of the small molecule 03A10 as an inhibitor of α-synuclein aggregation for Parkinson's disease treatment.
Wang et al. (2023)
3 more

2 mentions without citation

Advances towards Understanding the Mechanism of Action of the Hsp90 Complex.
Prodromou et al. (2022)
1 more