Function and Biology

Structural insights into viral RNA capping and plasma membrane targeting by Chikungunya virus nonstructural protein 1

Source organism: Chikungunya virus strain S27-African prototype
Biochemical function: mRNA methyltransferase activity
Biological process: mRNA modification
Cellular component: not assigned

EC 3.6.4.13: RNA helicase

Reaction catalysed:
ATP + H(2)O = ADP + phosphate
Systematic name:
ATP phosphohydrolase (RNA helix unwinding)
Alternative Name(s):
  • CSFV NS3 helicase
  • DBP2
  • DDX17
  • DDX25
  • DDX3
  • DDX3X
  • DDX3Y
  • DDX4
  • DDX5
  • DEAD-box RNA helicase
  • DEAD-box protein DED1
  • DEAH-box RNA helicase
  • DEAH-box protein 2
  • DED1
  • DbpA
  • Dex(H/D) RNA helicase
  • EIF4A helicase
  • EhDEAD1
  • EhDEAD1 RNA helicase
  • GRTH/DDX25
  • KOKV helicase
  • Mtr4p
  • NPH-II
  • Nonstructural protein 3 helicase
  • RHA
  • RNA helicase A
  • RNA helicase DDX3
  • RNA helicase Hera
  • RNA-dependent ATPase
  • TGBp1 NTPase/helicase domain
  • VRH1

EC 3.6.1.74: mRNA 5'-phosphatase

Reaction catalysed:
A 5'-triphospho-[mRNA] + H(2)O = a 5'-diphospho-[mRNA] + phosphate
Systematic name:
5'-triphospho-mRNA 5'-phosphohydrolase
Alternative Name(s):
  • 5'-polynucleotidase
  • Polynucleotide 5'-phosphohydrolase
  • mRNA 5'-triphosphate monophosphatase

EC 3.6.1.15: Nucleoside-triphosphate phosphatase

Reaction catalysed:
NTP + H(2)O = NDP + phosphate
Systematic name:
Unspecific diphosphate phosphohydrolase
Alternative Name(s):
  • NTPase
  • Nucleoside 5-triphosphatase
  • Nucleoside triphosphate hydrolase
  • Nucleoside triphosphate phosphohydrolase
  • Nucleoside-5-triphosphate phosphohydrolase
  • Nucleoside-triphosphatase

EC 3.1.3.84: ADP-ribose 1''-phosphate phosphatase

Reaction catalysed:
ADP-D-ribose 1''-phosphate + H(2)O = ADP-D-ribose + phosphate
Systematic name:
ADP-D-ribose 1''-phosphate phosphohydrolase
Alternative Name(s):
  • A-Ppr1p phosphatase
  • ADP-ribose 1''-phosphate phosphohydrolase
  • POA1
  • Poa1p

EC 2.7.7.48: RNA-directed RNA polymerase

Reaction catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Systematic name:
Nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)
Alternative Name(s):
  • 3D polymerase
  • PB1 proteins
  • PB2 proteins
  • Phage f2 replicase
  • Polymerase L
  • Q-beta replicase
  • RDRP
  • RNA nucleotidyltransferase (RNA-directed)
  • RNA replicase
  • RNA synthetase
  • RNA transcriptase
  • RNA-dependent RNA polymerase
  • RNA-dependent RNA replicase
  • RNA-dependent ribonucleate nucleotidyltransferase
  • Ribonucleic acid replicase
  • Ribonucleic acid-dependent ribonucleate nucleotidyltransferase
  • Ribonucleic acid-dependent ribonucleic acid polymerase
  • Ribonucleic replicase
  • Ribonucleic synthetase
  • Transcriptase

EC 2.7.7.19: Polynucleotide adenylyltransferase

Reaction catalysed:
ATP + RNA(n) = diphosphate + RNA(n+1)
Systematic name:
ATP:polynucleotide adenylyltransferase
Alternative Name(s):
  • AMP polynucleotidylexotransferase
  • ATP-polynucleotide adenylyltransferase
  • ATP:polynucleotidylexotransferase
  • Adenosine triphosphate:ribonucleic acid adenylyltransferase
  • NTP polymerase
  • Poly(A) hydrolase
  • Poly(A) polymerase
  • Poly(A) synthetase
  • Polyadenylate nucleotidyltransferase
  • Polyadenylate polymerase
  • Polyadenylate synthetase
  • Polyadenylic acid polymerase
  • Polyadenylic polymerase
  • RNA adenylating enzyme
  • RNA formation factors, PF1
  • Terminal riboadenylate transferase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF01660
Domain description: Viral methyltransferase
Occurring in:
  1. mRNA-capping enzyme nsP1
The deposited structure of PDB entry 7dop contains 12 copies of Pfam domain PF01660 (Viral methyltransferase) in mRNA-capping enzyme nsP1. Showing 1 copy in chain A.

InterPro InterPro annotation
IPR002588
Domain description: Alphavirus-like methyltransferase domain
Occurring in:
  1. mRNA-capping enzyme nsP1