› 7dqa

Electron Microscopy
2.8Å resolution

Cryo-EM structure of SARS-CoV2 RBD-ACE2 complex

Released:
DOI: 10.2210/pdb7dqa/pdb
PDB entry 7dqa coloured by chain, front view.
PDB entry 7dqa coloured by chain, side view.
PDB entry 7dqa coloured by chain, top view.
Source organisms:
Primary publication:
Reduced graphene oxide membrane as supporting film for high-resolution cryo-EM
Liu N, Zheng LM, Xu J, Wang J, Hu CX, Lan J, Zhang X, Zhang JC, Xu K, Cheng H, Yang Z, Gao X, Wang XQ, Peng HL, Chen YN, Wang HW
Biophys Rep 7 227-238 (2022)
Related structures: EMD-30816

Function and Biology Details

Reaction catalysed: 
Angiotensin II + H(2)O = angiotensin-(1-7) + L-phenylalanine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-144194 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Angiotensin-converting enzyme 2 Chain: A
Molecule details ›
Chain: A
Length: 805 amino acids
Theoretical weight: 92.56 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9BYF1 (Residues: 1-805; Coverage: 100%)
Gene names: ACE2, UNQ868/PRO1885
Sequence domains:
Spike protein S1 Chain: C
Molecule details ›
Chain: C
Length: 194 amino acids
Theoretical weight: 21.85 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 333-526; Coverage: 15%)
Gene names: 2, S
Sequence domains: Betacoronavirus spike glycoprotein S1, receptor binding

Ligands and Environments

3 bound ligands:
Ligand ZN 1 x ZN
Ligand CL 1 x CL
Ligand NAG 5 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.8Å
Relevant EMDB volumes: EMD-30816
Expression system: Homo sapiens

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