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FMDV capsid in complex with M170 Nab

Source organisms:
Biochemical function: structural molecule activity
Biological process: symbiont entry into host cell
Cellular component: icosahedral viral capsid

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EC 3.6.1.15: Nucleoside-triphosphate phosphatase

Reaction catalysed:
NTP + H(2)O = NDP + phosphate
Systematic name:
Unspecific diphosphate phosphohydrolase
Alternative Name(s):
  • NTPase
  • Nucleoside 5-triphosphatase
  • Nucleoside triphosphate hydrolase
  • Nucleoside triphosphate phosphohydrolase
  • Nucleoside-5-triphosphate phosphohydrolase
  • Nucleoside-triphosphatase

EC 3.4.22.46: L-peptidase

Reaction catalysed:
Autocatalytically cleaves itself from the polyprotein of the foot-and-mouth disease virus by hydrolysis of a Lys-|-Gly bond, but then cleaves host cell initiation factor eIF-4G at bonds -Gly-|-Arg- and -Lys-|-Arg-.
Systematic name:
-

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00073
Domain description: picornavirus capsid protein
Occurring in:
  1. VP2 of O type FMDV capsid
  2. VP3 of O type FMDV capsid
The deposited structure of PDB entry 7dst contains 1 copy of Pfam domain PF00073 (picornavirus capsid protein) in VP2 of O type FMDV capsid. Showing 1 copy in chain B.
The deposited structure of PDB entry 7dst contains 1 copy of Pfam domain PF00073 (picornavirus capsid protein) in VP3 of O type FMDV capsid. Showing 1 copy in chain C.

PF08935
Domain description: Viral protein VP4 subunit
Occurring in:
  1. VP4 of O type FMDV capsid
The deposited structure of PDB entry 7dst contains 1 copy of Pfam domain PF08935 (Viral protein VP4 subunit) in VP4 of O type FMDV capsid. Showing 1 copy in chain D.

PF22663
Domain description: Picornavirus coat protein
Occurring in:
  1. VP1 protein
The deposited structure of PDB entry 7dst contains 1 copy of Pfam domain PF22663 (Picornavirus coat protein) in VP1 protein. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR004080
Domain description: Foot-and-mouth disease virus VP1 coat
Occurring in:
  1. VP1 protein
IPR033703
Domain description: Picornavirus/Calicivirus coat protein
Occurring in:
  1. VP1 protein
  2. VP2 of O type FMDV capsid
  3. VP3 of O type FMDV capsid
IPR001676
Domain description: Picornavirus capsid
Occurring in:
  1. VP1 protein
  2. VP2 of O type FMDV capsid
  3. VP3 of O type FMDV capsid
IPR029053
Domain description: Viral coat protein subunit
Occurring in:
  1. VP1 protein
  2. VP2 of O type FMDV capsid
  3. VP3 of O type FMDV capsid
IPR013106
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. M170 Nab
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. M170 Nab
IPR003599
Domain description: Immunoglobulin domain subtype
Occurring in:
  1. M170 Nab
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. M170 Nab
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. M170 Nab
IPR037080
Domain description: Capsid protein VP4 superfamily, Picornavirus
Occurring in:
  1. VP4 of O type FMDV capsid
IPR015031
Domain description: Capsid protein VP4, Picornavirus
Occurring in:
  1. VP4 of O type FMDV capsid

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