7dsx

Electron Microscopy
3.5Å resolution

Structure of a human NHE1-CHP1 complex under pH 7.5, bound by cariporide

Released:
Source organism: Homo sapiens
Primary publication:
Structure and mechanism of the human NHE1-CHP1 complex.
OpenAccess logo Nat Commun 12 3474 (2021)
PMID: 34108458
Related structures: EMD-30849

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-148676 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Calcineurin B homologous protein 1 Chains: C, D
Molecule details ›
Chains: C, D
Length: 185 amino acids
Theoretical weight: 21.37 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q99653 (Residues: 11-195; Coverage: 95%)
Gene names: CHP, CHP1
Sequence domains: EF hand
Sodium/hydrogen exchanger 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 509 amino acids
Theoretical weight: 57.1 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P19634 (Residues: 85-593; Coverage: 63%)
Gene names: APNH1, NHE1, SLC9A1
Sequence domains: Sodium/hydrogen exchanger family

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.5Å
Relevant EMDB volumes: EMD-30849
Expression system: Homo sapiens